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Oral alitretinoin for the treatment of recalcitrant pityriasis rubra pilaris.

Schmitt L, Inhoff O, Dippel E - Case Rep Dermatol (2011)

Bottom Line: After a few weeks, skin condition improved significantly and itching and scaling disappeared.The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I.Further studies are needed to investigate the benefit of this encouraging result.

View Article: PubMed Central - PubMed

Affiliation: Dermatology Clinic, Clinical Centre of the City of Ludwigshafen, Ludwigshafen am Rhein, Germany.

ABSTRACT
Treatment of pityriasis rubra pilaris is still challenging. We here present a 74-year-old woman who had not experienced stable remission of her skin symptoms during prior treatments including topical and systemic corticosteroids, phototherapy, orally administered acitretin, cyclosporine, methotrexate and adalimumab. A therapy with oral alitretinoin was started and tolerated very well. After a few weeks, skin condition improved significantly and itching and scaling disappeared. The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result.

No MeSH data available.


Related in: MedlinePlus

After 5 months of therapy with alitretinoin, the skin condition of our patient improved significantly with only slight residua of erythematous patches.
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Figure 2: After 5 months of therapy with alitretinoin, the skin condition of our patient improved significantly with only slight residua of erythematous patches.

Mentions: In April 2010, a therapeutic regimen with oral systemic alitretinoin 30 mg daily was started and very well tolerated. Bland emollients and initially topical corticosteroids were used. The skin condition of our patient improved significantly within weeks and also the itching and scaling disappeared (fig. 2). Treatment with oral alitretinoin 30 mg has been ongoing since 7 months now. No rising of serum cholesterol or triglyceride levels have been recognized. However, hair loss has progressed significantly under therapy with alitretinoin, and the patient had to be provided with a wig. Despite this invasive cosmetic effect related to the medication, the benefits of the therapy outweigh and a continuation of the therapy has been requested by the patient.


Oral alitretinoin for the treatment of recalcitrant pityriasis rubra pilaris.

Schmitt L, Inhoff O, Dippel E - Case Rep Dermatol (2011)

After 5 months of therapy with alitretinoin, the skin condition of our patient improved significantly with only slight residua of erythematous patches.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3094680&req=5

Figure 2: After 5 months of therapy with alitretinoin, the skin condition of our patient improved significantly with only slight residua of erythematous patches.
Mentions: In April 2010, a therapeutic regimen with oral systemic alitretinoin 30 mg daily was started and very well tolerated. Bland emollients and initially topical corticosteroids were used. The skin condition of our patient improved significantly within weeks and also the itching and scaling disappeared (fig. 2). Treatment with oral alitretinoin 30 mg has been ongoing since 7 months now. No rising of serum cholesterol or triglyceride levels have been recognized. However, hair loss has progressed significantly under therapy with alitretinoin, and the patient had to be provided with a wig. Despite this invasive cosmetic effect related to the medication, the benefits of the therapy outweigh and a continuation of the therapy has been requested by the patient.

Bottom Line: After a few weeks, skin condition improved significantly and itching and scaling disappeared.The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I.Further studies are needed to investigate the benefit of this encouraging result.

View Article: PubMed Central - PubMed

Affiliation: Dermatology Clinic, Clinical Centre of the City of Ludwigshafen, Ludwigshafen am Rhein, Germany.

ABSTRACT
Treatment of pityriasis rubra pilaris is still challenging. We here present a 74-year-old woman who had not experienced stable remission of her skin symptoms during prior treatments including topical and systemic corticosteroids, phototherapy, orally administered acitretin, cyclosporine, methotrexate and adalimumab. A therapy with oral alitretinoin was started and tolerated very well. After a few weeks, skin condition improved significantly and itching and scaling disappeared. The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result.

No MeSH data available.


Related in: MedlinePlus