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Biodegradable chitosan-based ambroxol hydrochloride microspheres: effect of cross-linking agents.

Gangurde H, Chavan N, Mundada A, Derle D, Tamizharasi S - J Young Pharm (2011)

Bottom Line: The DSC, XRD, and FTIR analysis showed that chitosan microspheres cross linked by heating were superior in properties and performance as compared to the microspheres cross-linked using formaldehyde.SEM results revealed that heat-treated microspheres were spherical, discrete having smooth, and porous structure.The particle size and encapsulation efficiencies of the prepared chitosan microspheres ranged between 10.83-24.11 μm and 39.73μ80.56%, respectively.

View Article: PubMed Central - PubMed

Affiliation: SNJB's Shriman Suresh Dada Jain College of Pharmacy, Neminagar, Chandwad, Nasik, Maharastra, India.

ABSTRACT
The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using formaldehyde and heat treatment. Morphological and physicochemical properties of microspheres were then investigated by scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) spectroscopy. The cross-linking of chitosan takes place at the free amino group because of formation of imine bond as evidenced by FTIR. The DSC, XRD, and FTIR analysis showed that chitosan microspheres cross linked by heating were superior in properties and performance as compared to the microspheres cross-linked using formaldehyde. SEM results revealed that heat-treated microspheres were spherical, discrete having smooth, and porous structure. The particle size and encapsulation efficiencies of the prepared chitosan microspheres ranged between 10.83-24.11 μm and 39.73μ80.56%, respectively. The drug release was extended up to 12 h, and the kinetics of the drug release was obeying Higuchi kinetic proving diffusion-controlled drug release.

No MeSH data available.


Related in: MedlinePlus

Comparative in vitro dissolution profile of optimized H3 microspheres with marketed capsule M1. ● M1; ○ H3
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Figure 0003: Comparative in vitro dissolution profile of optimized H3 microspheres with marketed capsule M1. ● M1; ○ H3

Mentions: Similarity factor (f2) and difference factor (f1) were calculated for optimized microspheres considering marketed capsule as the reference standard. It was found that f1 and f2 value for H3 were 51.83 and 3.06, respectively. This suggested that H3 microspheres showed similarities of dissolution profiles with that of marketed capsule Figure 3. T90% of H3 and marketed capsule was 10.3 and 9.48 h, respectively, which suggested that these microspheres showed release profiles comparable with that of marketed capsule.


Biodegradable chitosan-based ambroxol hydrochloride microspheres: effect of cross-linking agents.

Gangurde H, Chavan N, Mundada A, Derle D, Tamizharasi S - J Young Pharm (2011)

Comparative in vitro dissolution profile of optimized H3 microspheres with marketed capsule M1. ● M1; ○ H3
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094564&req=5

Figure 0003: Comparative in vitro dissolution profile of optimized H3 microspheres with marketed capsule M1. ● M1; ○ H3
Mentions: Similarity factor (f2) and difference factor (f1) were calculated for optimized microspheres considering marketed capsule as the reference standard. It was found that f1 and f2 value for H3 were 51.83 and 3.06, respectively. This suggested that H3 microspheres showed similarities of dissolution profiles with that of marketed capsule Figure 3. T90% of H3 and marketed capsule was 10.3 and 9.48 h, respectively, which suggested that these microspheres showed release profiles comparable with that of marketed capsule.

Bottom Line: The DSC, XRD, and FTIR analysis showed that chitosan microspheres cross linked by heating were superior in properties and performance as compared to the microspheres cross-linked using formaldehyde.SEM results revealed that heat-treated microspheres were spherical, discrete having smooth, and porous structure.The particle size and encapsulation efficiencies of the prepared chitosan microspheres ranged between 10.83-24.11 μm and 39.73μ80.56%, respectively.

View Article: PubMed Central - PubMed

Affiliation: SNJB's Shriman Suresh Dada Jain College of Pharmacy, Neminagar, Chandwad, Nasik, Maharastra, India.

ABSTRACT
The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using formaldehyde and heat treatment. Morphological and physicochemical properties of microspheres were then investigated by scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) spectroscopy. The cross-linking of chitosan takes place at the free amino group because of formation of imine bond as evidenced by FTIR. The DSC, XRD, and FTIR analysis showed that chitosan microspheres cross linked by heating were superior in properties and performance as compared to the microspheres cross-linked using formaldehyde. SEM results revealed that heat-treated microspheres were spherical, discrete having smooth, and porous structure. The particle size and encapsulation efficiencies of the prepared chitosan microspheres ranged between 10.83-24.11 μm and 39.73μ80.56%, respectively. The drug release was extended up to 12 h, and the kinetics of the drug release was obeying Higuchi kinetic proving diffusion-controlled drug release.

No MeSH data available.


Related in: MedlinePlus