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Anticancer Evaluation of Adiantum venustum Don.

Viral D, Shivanand P, Jivani N - J Young Pharm (2011)

Bottom Line: Next to heart disease, cancer is a major killer of mankind.This study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum venustum Don against Ehrlich Ascites Carcinoma in animal model.The findings indicate that ethanolic extract of A. venustum Don possesses significant anticancer activity and also reduces elevated level of lipid peroxidation due to the presence of terpenoids and flavonoids.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Chemistry, Smt. R. B. P. Mahila Pharmacy College, Atkot, India.

ABSTRACT
Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumor, or proliferate throughout the body. Next to heart disease, cancer is a major killer of mankind. This study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum venustum Don against Ehrlich Ascites Carcinoma in animal model. The findings indicate that ethanolic extract of A. venustum Don possesses significant anticancer activity and also reduces elevated level of lipid peroxidation due to the presence of terpenoids and flavonoids. Thus, ethanolic extract of A. venustum Don could have vast therapeutic application against cancer.

No MeSH data available.


Related in: MedlinePlus

Graphical representation of Mean survival time and % increase in life span of mice
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Figure 0002: Graphical representation of Mean survival time and % increase in life span of mice

Mentions: In acute toxicity study, the given extract of A. venustum did not show any mortality up to the dose of 2000 mg/kg. It is safe dose that was determined by organization for economic cooperation and development (OECD) guidelines. The extract shows sedation, hypnosis, and mild muscle relaxant property. Administration of EEAV reduces the tumor volume, packed cell volume, and viable tumor cell count in a dose-dependant manner when compared to EAC control mice. In EAC control mice, the median survival time was 22 ± 0.25 days. Whereas, it was significant increased median survival time (24 ± 0.33, 29 ± 0.49) with different doses (150 and 250 mg/kg) of EEAV and standard drug, respectively. The mean survival time (MST) and the effect of EEAV (150 and 250 mg/kg) at different doses on tumor volume, viable, and nonviable cell count, were shown in Tables 2 and 3 and graphical representation are shown in Figures 2 and 3.


Anticancer Evaluation of Adiantum venustum Don.

Viral D, Shivanand P, Jivani N - J Young Pharm (2011)

Graphical representation of Mean survival time and % increase in life span of mice
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094560&req=5

Figure 0002: Graphical representation of Mean survival time and % increase in life span of mice
Mentions: In acute toxicity study, the given extract of A. venustum did not show any mortality up to the dose of 2000 mg/kg. It is safe dose that was determined by organization for economic cooperation and development (OECD) guidelines. The extract shows sedation, hypnosis, and mild muscle relaxant property. Administration of EEAV reduces the tumor volume, packed cell volume, and viable tumor cell count in a dose-dependant manner when compared to EAC control mice. In EAC control mice, the median survival time was 22 ± 0.25 days. Whereas, it was significant increased median survival time (24 ± 0.33, 29 ± 0.49) with different doses (150 and 250 mg/kg) of EEAV and standard drug, respectively. The mean survival time (MST) and the effect of EEAV (150 and 250 mg/kg) at different doses on tumor volume, viable, and nonviable cell count, were shown in Tables 2 and 3 and graphical representation are shown in Figures 2 and 3.

Bottom Line: Next to heart disease, cancer is a major killer of mankind.This study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum venustum Don against Ehrlich Ascites Carcinoma in animal model.The findings indicate that ethanolic extract of A. venustum Don possesses significant anticancer activity and also reduces elevated level of lipid peroxidation due to the presence of terpenoids and flavonoids.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Chemistry, Smt. R. B. P. Mahila Pharmacy College, Atkot, India.

ABSTRACT
Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumor, or proliferate throughout the body. Next to heart disease, cancer is a major killer of mankind. This study aims at a preliminary phytochemical screening and anticancer evaluation of Adiantum venustum Don against Ehrlich Ascites Carcinoma in animal model. The findings indicate that ethanolic extract of A. venustum Don possesses significant anticancer activity and also reduces elevated level of lipid peroxidation due to the presence of terpenoids and flavonoids. Thus, ethanolic extract of A. venustum Don could have vast therapeutic application against cancer.

No MeSH data available.


Related in: MedlinePlus