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Antiurolithiatic Activity of Whole-Plant Hydroalcoholic Extract of Pergularia daemia in Rats.

Vyas B, Vyas R, Joshi S, Santani D - J Young Pharm (2011)

Bottom Line: Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract.The results were comparable with the standard drug, cystone (750 mg/kg).The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract.

View Article: PubMed Central - PubMed

Affiliation: Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat - 394 350, India.

ABSTRACT
The whole-plant, Pergularia daemia (Family: Asclepediaceae), extract (50% alcohol) was investigated for its antiurolithiatic and diuretic activity. Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Alcoholic extract (400 mg/kg) of P. daemia was given orally in curative and preventive regimens over a period of 28 days. Supplementation with extract significantly (P < 0.001) lowered the urinary excretion and kidney retention levels of oxalate, calcium and phosphate. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract. The results were comparable with the standard drug, cystone (750 mg/kg). The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract. The extract exhibited significant diuretic activity at dose of 400 mg/kg body weight as evidenced by increased total urine volume and the urine concentration of Na(+), and K(+). These findings affirm assertions made regarding the effectiveness of the extract of this plant against urinary pathologies in the Indian folk medicine.

No MeSH data available.


Related in: MedlinePlus

Effect of P. daemia extract on kidney parameters in control and experimental animals (All values represent mean ± S.E.M, N = 6, * P < 0.001, compared to control Group I, N = 6, ** P < 0.001, compared to ethylene glycol Group II, One-way analysis of variance (ANOVA) followed by “Dunnett’s test.”)
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Figure 0002: Effect of P. daemia extract on kidney parameters in control and experimental animals (All values represent mean ± S.E.M, N = 6, * P < 0.001, compared to control Group I, N = 6, ** P < 0.001, compared to ethylene glycol Group II, One-way analysis of variance (ANOVA) followed by “Dunnett’s test.”)

Mentions: Hyperoxaluria and hypercalciuria are major risk factors for the pathogenesis of renal stones. Since hyperoxaluria is a far more significant risk factor, the changes in urinary oxalate levels are comparatively much more imperative than those of calcium.[16] Increased urinary and kidney calcium is a factor stimulating the nucleation and precipitation of calcium oxalate or apatite (calcium phosphate) from urine and following crystal growth.[17] However, in the present study, supplementation with Pergularia daemia extract and Cystone restored oxalate and calcium in urine and kidney in curative regimens and preventive regimens as compared to calculi-treated animals [Figures 1 and 2].


Antiurolithiatic Activity of Whole-Plant Hydroalcoholic Extract of Pergularia daemia in Rats.

Vyas B, Vyas R, Joshi S, Santani D - J Young Pharm (2011)

Effect of P. daemia extract on kidney parameters in control and experimental animals (All values represent mean ± S.E.M, N = 6, * P < 0.001, compared to control Group I, N = 6, ** P < 0.001, compared to ethylene glycol Group II, One-way analysis of variance (ANOVA) followed by “Dunnett’s test.”)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094557&req=5

Figure 0002: Effect of P. daemia extract on kidney parameters in control and experimental animals (All values represent mean ± S.E.M, N = 6, * P < 0.001, compared to control Group I, N = 6, ** P < 0.001, compared to ethylene glycol Group II, One-way analysis of variance (ANOVA) followed by “Dunnett’s test.”)
Mentions: Hyperoxaluria and hypercalciuria are major risk factors for the pathogenesis of renal stones. Since hyperoxaluria is a far more significant risk factor, the changes in urinary oxalate levels are comparatively much more imperative than those of calcium.[16] Increased urinary and kidney calcium is a factor stimulating the nucleation and precipitation of calcium oxalate or apatite (calcium phosphate) from urine and following crystal growth.[17] However, in the present study, supplementation with Pergularia daemia extract and Cystone restored oxalate and calcium in urine and kidney in curative regimens and preventive regimens as compared to calculi-treated animals [Figures 1 and 2].

Bottom Line: Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract.The results were comparable with the standard drug, cystone (750 mg/kg).The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract.

View Article: PubMed Central - PubMed

Affiliation: Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat - 394 350, India.

ABSTRACT
The whole-plant, Pergularia daemia (Family: Asclepediaceae), extract (50% alcohol) was investigated for its antiurolithiatic and diuretic activity. Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Alcoholic extract (400 mg/kg) of P. daemia was given orally in curative and preventive regimens over a period of 28 days. Supplementation with extract significantly (P < 0.001) lowered the urinary excretion and kidney retention levels of oxalate, calcium and phosphate. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract. The results were comparable with the standard drug, cystone (750 mg/kg). The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract. The extract exhibited significant diuretic activity at dose of 400 mg/kg body weight as evidenced by increased total urine volume and the urine concentration of Na(+), and K(+). These findings affirm assertions made regarding the effectiveness of the extract of this plant against urinary pathologies in the Indian folk medicine.

No MeSH data available.


Related in: MedlinePlus