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Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet.

Chabukswar A, Jagdale S, Kuchekar B, Joshi V, Deshmukh G, Kothawade H, Kuckekar A, Lokhande P - J Young Pharm (2011)

Bottom Line: PUCC is an iterative approach that rotates between the three pillars of the process of understanding, process control, and process capability, with each iteration resulting in a more capable and robust process.It is rightly said that being at the top is a marathon and not a sprint.The application of six sigma led to an improved process capability, due to the improved sigma level of the process from 1.5 to 4, a higher yield, due to reduced variation and reduction of thick tablets, reduction in packing line stoppages, reduction in re-work by 50%, a more standardized process, with smooth flow and change in coating suspension reconstitution level (8%w/w), a huge cost reduction of approximately Rs.90 to 95 lakhs per annum, an improved overall efficiency by 30% approximately, and improved overall quality of the product.

View Article: PubMed Central - PubMed

Affiliation: MAEER's Maharashtra Institute of Pharmacy, MIT Campus, Paud Road, Kothrud, Pune - 411 038, India.

ABSTRACT
The process of understanding the control and capability (PUCC) is an iterative closed loop process for continuous improvement. It covers the DMAIC toolkit in its three phases. PUCC is an iterative approach that rotates between the three pillars of the process of understanding, process control, and process capability, with each iteration resulting in a more capable and robust process. It is rightly said that being at the top is a marathon and not a sprint. The objective of the six sigma study of Ranitidine hydrochloride tablets is to achieve perfection in tablet manufacturing by reviewing the present robust manufacturing process, to find out ways to improve and modify the process, which will yield tablets that are defect-free and will give more customer satisfaction. The application of six sigma led to an improved process capability, due to the improved sigma level of the process from 1.5 to 4, a higher yield, due to reduced variation and reduction of thick tablets, reduction in packing line stoppages, reduction in re-work by 50%, a more standardized process, with smooth flow and change in coating suspension reconstitution level (8%w/w), a huge cost reduction of approximately Rs.90 to 95 lakhs per annum, an improved overall efficiency by 30% approximately, and improved overall quality of the product.

No MeSH data available.


Related in: MedlinePlus

Cumulative spray rate variation per day in pan 4 of the coating phase
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Figure 0014: Cumulative spray rate variation per day in pan 4 of the coating phase

Mentions: Considerable cumulative Spray rate variation [Tables 6 and 7], Figures 14 and 15 as well as individual gun spray rate variation (50 ml – 450 ml) was observed, in order to solve this variation, Gun maintenance and replacement was done and when required chocking of guns to be minimized or eradicated and also gun cleaning frequency and its effectiveness to be addressed.


Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet.

Chabukswar A, Jagdale S, Kuchekar B, Joshi V, Deshmukh G, Kothawade H, Kuckekar A, Lokhande P - J Young Pharm (2011)

Cumulative spray rate variation per day in pan 4 of the coating phase
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094555&req=5

Figure 0014: Cumulative spray rate variation per day in pan 4 of the coating phase
Mentions: Considerable cumulative Spray rate variation [Tables 6 and 7], Figures 14 and 15 as well as individual gun spray rate variation (50 ml – 450 ml) was observed, in order to solve this variation, Gun maintenance and replacement was done and when required chocking of guns to be minimized or eradicated and also gun cleaning frequency and its effectiveness to be addressed.

Bottom Line: PUCC is an iterative approach that rotates between the three pillars of the process of understanding, process control, and process capability, with each iteration resulting in a more capable and robust process.It is rightly said that being at the top is a marathon and not a sprint.The application of six sigma led to an improved process capability, due to the improved sigma level of the process from 1.5 to 4, a higher yield, due to reduced variation and reduction of thick tablets, reduction in packing line stoppages, reduction in re-work by 50%, a more standardized process, with smooth flow and change in coating suspension reconstitution level (8%w/w), a huge cost reduction of approximately Rs.90 to 95 lakhs per annum, an improved overall efficiency by 30% approximately, and improved overall quality of the product.

View Article: PubMed Central - PubMed

Affiliation: MAEER's Maharashtra Institute of Pharmacy, MIT Campus, Paud Road, Kothrud, Pune - 411 038, India.

ABSTRACT
The process of understanding the control and capability (PUCC) is an iterative closed loop process for continuous improvement. It covers the DMAIC toolkit in its three phases. PUCC is an iterative approach that rotates between the three pillars of the process of understanding, process control, and process capability, with each iteration resulting in a more capable and robust process. It is rightly said that being at the top is a marathon and not a sprint. The objective of the six sigma study of Ranitidine hydrochloride tablets is to achieve perfection in tablet manufacturing by reviewing the present robust manufacturing process, to find out ways to improve and modify the process, which will yield tablets that are defect-free and will give more customer satisfaction. The application of six sigma led to an improved process capability, due to the improved sigma level of the process from 1.5 to 4, a higher yield, due to reduced variation and reduction of thick tablets, reduction in packing line stoppages, reduction in re-work by 50%, a more standardized process, with smooth flow and change in coating suspension reconstitution level (8%w/w), a huge cost reduction of approximately Rs.90 to 95 lakhs per annum, an improved overall efficiency by 30% approximately, and improved overall quality of the product.

No MeSH data available.


Related in: MedlinePlus