Efficacy and complications of neurosurgical treatment of acromegaly.
Bottom Line: In patients cured by surgery, lower levels of basal GH (P<0.05), IGF-1 (P<0.001), GH at 120 min in OGTT and smaller size of pituitary tumour (P<0.05) were found at diagnosis, as compared to patients in whom surgery was unsuccessful.Significant correlation between basal serum level of GH at diagnosis and size of pituitary tumour was found (P<0.001).Invasive tumours were found in 45 of 53 (84.9%) patients not cured and in only 8 of 32 (25.0%) patients cured (P<0.001).
Affiliation: Department of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501 Kraków, Poland.Show MeSH
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Mentions: In 5 out of 12 patients with poly- or mono-axial hypopituitarism prior to surgery, worsening of pituitary function was found post-surgery, while in 1 patient no change was observed. In 6 patients normal sufficient pituitary function was restored (Fig. 4). Worsening of pituitary function was defined as failure of a higher number of hormonal axes than prior to surgery.Fig. 4
Affiliation: Department of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501 Kraków, Poland.