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The Office of Health Assessment and Translation: a problem-solving resource for the National Toxicology Program.

Bucher JR, Thayer K, Birnbaum LS - Environ. Health Perspect. (2011)

View Article: PubMed Central - PubMed

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The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) was established in 1998... CERHR served as an environmental health resource providing in-depth scientific assessments of effects on reproduction and development caused by agents to which humans are exposed... To provide this, CERHR has spent the last 2 years in transition, laying the groundwork to become a more flexible scientific analysis program, while continuing to be grounded and recognized as a unique and important public health resource for the interpretation of reproductive and developmental hazards to humans... This evolution of CERHR is a response to the changing and increasing demands on both the NTP analysis and research programs. ”What does it mean?” is a question we increasingly want to answer, as our research and testing tools become more sophisticated and mechanistically based... A change in CERHR’s scope will also bring its work more in line with two recent initiatives established within the NTP that have mandates to address a broad range of health effects... In 2007 the NTP established a biomolecular screening program to administer its High Throughput Screening (HTS) Initiative in collaboration with our Tox21 partners... This program takes advantage of technological advances in molecular biology and computer science to screen for mechanistic targets or “toxicity pathways” considered critical to adverse health effects... These exciting findings are now being collated for publication... To fulfill its mission, the NTP is developing more innovative and flexible approaches for information and data integration, both across different programs within the NTP and across the different types of data that are generated and utilized (i.e., mechanistic or high throughput; “hypothesis-driven” animal studies of the type undertaken by National Institute of Environmental Health Sciences (NIEHS)-funded extramural grantees; and toxicology studies conducted for the purpose of safety assessment)... The evolution of CERHR is an important part of this information integration effort, and CERHR’s new role calls for a new name: the Office of Health Assessment and Translation... Under the leadership of Kristina Thayer, the Office of Health Assessment and Translation will be the NTP focal point for the thoughtful and deliberative integration of relevant information of all types in health assessments for the protection of public health.

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Linda S. Birnbaum
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The Office of Health Assessment and Translation: a problem-solving resource for the National Toxicology Program.

Bucher JR, Thayer K, Birnbaum LS - Environ. Health Perspect. (2011)

Linda S. Birnbaum
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094430&req=5

f3-ehp-119-a196: Linda S. Birnbaum

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) was established in 1998... CERHR served as an environmental health resource providing in-depth scientific assessments of effects on reproduction and development caused by agents to which humans are exposed... To provide this, CERHR has spent the last 2 years in transition, laying the groundwork to become a more flexible scientific analysis program, while continuing to be grounded and recognized as a unique and important public health resource for the interpretation of reproductive and developmental hazards to humans... This evolution of CERHR is a response to the changing and increasing demands on both the NTP analysis and research programs. ”What does it mean?” is a question we increasingly want to answer, as our research and testing tools become more sophisticated and mechanistically based... A change in CERHR’s scope will also bring its work more in line with two recent initiatives established within the NTP that have mandates to address a broad range of health effects... In 2007 the NTP established a biomolecular screening program to administer its High Throughput Screening (HTS) Initiative in collaboration with our Tox21 partners... This program takes advantage of technological advances in molecular biology and computer science to screen for mechanistic targets or “toxicity pathways” considered critical to adverse health effects... These exciting findings are now being collated for publication... To fulfill its mission, the NTP is developing more innovative and flexible approaches for information and data integration, both across different programs within the NTP and across the different types of data that are generated and utilized (i.e., mechanistic or high throughput; “hypothesis-driven” animal studies of the type undertaken by National Institute of Environmental Health Sciences (NIEHS)-funded extramural grantees; and toxicology studies conducted for the purpose of safety assessment)... The evolution of CERHR is an important part of this information integration effort, and CERHR’s new role calls for a new name: the Office of Health Assessment and Translation... Under the leadership of Kristina Thayer, the Office of Health Assessment and Translation will be the NTP focal point for the thoughtful and deliberative integration of relevant information of all types in health assessments for the protection of public health.

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