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Phagocytic ability of neutrophils and monocytes in neonates.

Filias A, Theodorou GL, Mouzopoulou S, Varvarigou AA, Mantagos S, Karakantza M - BMC Pediatr (2011)

Bottom Line: The phagocytic ability of neutrophils in the cord blood of neonates was significantly reduced compared to adults.Coli by phagocytes is impaired at birth in both preterm and full term neonates compared to adults.This defect is transient, with the phagocytic ability in neonates reaching that of the adults 3 days after birth.

View Article: PubMed Central - HTML - PubMed

Affiliation: Paediatric Department, Medical School & University Hospital, University of Patras, Patras, Greece.

ABSTRACT

Background: Infections by a variety of pathogens are a significant cause of morbidity and mortality during perinatal period. The susceptibility of neonates to bacterial infections has been attributed to immaturity of innate immunity. It is considered that one of the impaired mechanisms is the phagocytic function of neutrophils and monocytes. The purpose of the present study was to investigate the phagocytic ability of neonates at birth.

Methods: The phagocytic ability of neutrophils and monocytes of 42 neonates was determined using the Phagotest flow cytometry method, that assesses the intake of E. Coli by phagocytes, in cord blood and in peripheral blood 3 days after birth. Fifteen healthy adults were included in the study as controls.

Results: The phagocytic ability of neutrophils in the cord blood of neonates was significantly reduced compared to adults. The 3rd postnatal day the reduction of phagocytic ability of neutrophils was no longer significant compared to adults. The phagocytic ability of monocytes did not show any difference from that of adults either at birth or the 3rd postnatal day.

Conclusions: Our findings indicate that the intake of E. Coli by phagocytes is impaired at birth in both preterm and full term neonates compared to adults. This defect is transient, with the phagocytic ability in neonates reaching that of the adults 3 days after birth.

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Correlations of phagocytic ability of monocytes with birth weight, and absolute number of neutrophils with gestational age of the neonates.
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Figure 2: Correlations of phagocytic ability of monocytes with birth weight, and absolute number of neutrophils with gestational age of the neonates.

Mentions: Spearman rank correlation showed a significant relation of birth weight with the phagocytic ability of monocytes (r = 0.366, P = 0.033) and of gestational age with the absolute number of the neutrophils (r = 0.501, P = 0.003) (Figure 2). It did not show any significant correlation between gestation age and monocyte and neutrophil phagocytosis. This finding might be due to the small number of preterm neonates included in the study and the fact that all of them were late preterm neonates.


Phagocytic ability of neutrophils and monocytes in neonates.

Filias A, Theodorou GL, Mouzopoulou S, Varvarigou AA, Mantagos S, Karakantza M - BMC Pediatr (2011)

Correlations of phagocytic ability of monocytes with birth weight, and absolute number of neutrophils with gestational age of the neonates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3094219&req=5

Figure 2: Correlations of phagocytic ability of monocytes with birth weight, and absolute number of neutrophils with gestational age of the neonates.
Mentions: Spearman rank correlation showed a significant relation of birth weight with the phagocytic ability of monocytes (r = 0.366, P = 0.033) and of gestational age with the absolute number of the neutrophils (r = 0.501, P = 0.003) (Figure 2). It did not show any significant correlation between gestation age and monocyte and neutrophil phagocytosis. This finding might be due to the small number of preterm neonates included in the study and the fact that all of them were late preterm neonates.

Bottom Line: The phagocytic ability of neutrophils in the cord blood of neonates was significantly reduced compared to adults.Coli by phagocytes is impaired at birth in both preterm and full term neonates compared to adults.This defect is transient, with the phagocytic ability in neonates reaching that of the adults 3 days after birth.

View Article: PubMed Central - HTML - PubMed

Affiliation: Paediatric Department, Medical School & University Hospital, University of Patras, Patras, Greece.

ABSTRACT

Background: Infections by a variety of pathogens are a significant cause of morbidity and mortality during perinatal period. The susceptibility of neonates to bacterial infections has been attributed to immaturity of innate immunity. It is considered that one of the impaired mechanisms is the phagocytic function of neutrophils and monocytes. The purpose of the present study was to investigate the phagocytic ability of neonates at birth.

Methods: The phagocytic ability of neutrophils and monocytes of 42 neonates was determined using the Phagotest flow cytometry method, that assesses the intake of E. Coli by phagocytes, in cord blood and in peripheral blood 3 days after birth. Fifteen healthy adults were included in the study as controls.

Results: The phagocytic ability of neutrophils in the cord blood of neonates was significantly reduced compared to adults. The 3rd postnatal day the reduction of phagocytic ability of neutrophils was no longer significant compared to adults. The phagocytic ability of monocytes did not show any difference from that of adults either at birth or the 3rd postnatal day.

Conclusions: Our findings indicate that the intake of E. Coli by phagocytes is impaired at birth in both preterm and full term neonates compared to adults. This defect is transient, with the phagocytic ability in neonates reaching that of the adults 3 days after birth.

Show MeSH
Related in: MedlinePlus