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Relationship between TNF- gene promoter polymorphisms and outcomes of hepatitis B virus infections: a meta-analysis.

Xia Q, Zhou L, Liu D, Chen Z, Chen F - PLoS ONE (2011)

Bottom Line: The data showed that TNF-<alpha>-863 CC genotype was significantly associated with HBV clearance (-863 CC vs.For the other polymorphisms, no association with HBV infection outcome was found.Furthermore, ethnicity might play an important role in HBV infection outcome, leading to conflicting results.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Infectious Disease Diagnosis and Treatment, College of Medicine, First Affiliated Hospital, Zhejiang University, Zhejiang, China.

ABSTRACT

Background: The clearance of hepatitis B virus (HBV) is a complex process which may be influenced by many factors including polymorphisms in the tumor necrosis factor (TNF-) gene promoter. However, previous reports regarding the relationship between polymorphisms in the TNF- promoter and HBV clearance have been inconsistent. Therefore, we performed a meta-analysis on a large population to address this inconsistency.

Methods: A meta-analysis was performed to examine the association between TNF- promoter polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A and-238G/A) and chronic hepatitis B infection. Odds ratio (OR) and its 95 % confidence interval (CI) were used.

Results: Twelve studies were chosen in our meta-analysis, involving 2,754 chronic HBV infection cases and 1,630 HBV clearance cases. The data showed that TNF--863 CC genotype was significantly associated with HBV clearance (-863 CC vs. AA: OR, 0.64; 95% CI, [0.42, 0.97]; p = 0.04) while patients carrying -308 GG genotype had a significantly increased risk of HBV persistence compared with those with GA or AA genotype (GG vs. GA+AA: OR, 1.35; 95% CI, [1.08, 1.70]; p = 0.01). For the other polymorphisms, no association with HBV infection outcome was found.

Conclusions: The data showed that polymorphisms -863 A and -308 G in the TNF- gene promoter region might be risk factors for HBV persistence. Furthermore, ethnicity might play an important role in HBV infection outcome, leading to conflicting results. More studies on individuals from various ethnic groups will be necessary to determine the role of TNF- promoter polymorphisms in the outcome of HBV infection.

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Related in: MedlinePlus

Funnel plot analysis to examine publication bias.Some asymmetry in -863 CC vs. AA (A) and -863 AA vs. CA+CC (A). After one study removed, the publication bias was eliminated. See -863 CC vs. AA (B) and -863 AA vs. CA+CC (B).
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pone-0019606-g004: Funnel plot analysis to examine publication bias.Some asymmetry in -863 CC vs. AA (A) and -863 AA vs. CA+CC (A). After one study removed, the publication bias was eliminated. See -863 CC vs. AA (B) and -863 AA vs. CA+CC (B).

Mentions: Begg's funnel plot and Egger's test were performed to access the publication bias of the studies. No evidence of publication bias showed in -308 G allele vs. A allele or -308 GG vs. AA model (funnel plot data not show, Egger's test p = 0.470 and 0.556,respectively). However, funnel plot showed some asymmetry in -863 CC vs. AA and -863 AA vs. CA+CC models(Fig 4) and Egger's proved the existence of publication in these two models(p = 0.041 and 0.038, respectively). We excluded one study from the meta-analysis to see whether the publication bias still presented. The results showed that after the exclusion of study Chen, D. Q. et al [6], the publication bias was eliminated(funnel plot showed in Fig 4, Egger's test -863 CC vs. AA:p = 0.785; -863 AA vs. CA+CC:p = 0.541),and the conclusion still stable(-863 CC vs. AA: OR, 0.42; 95% CI, [0.23, 0.77]; p = 0.005; -863 AA vs. CA+CC: OR, 2.44; 95% CI, [1.34, 4.45]; p = 0.003).


Relationship between TNF- gene promoter polymorphisms and outcomes of hepatitis B virus infections: a meta-analysis.

Xia Q, Zhou L, Liu D, Chen Z, Chen F - PLoS ONE (2011)

Funnel plot analysis to examine publication bias.Some asymmetry in -863 CC vs. AA (A) and -863 AA vs. CA+CC (A). After one study removed, the publication bias was eliminated. See -863 CC vs. AA (B) and -863 AA vs. CA+CC (B).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3091871&req=5

pone-0019606-g004: Funnel plot analysis to examine publication bias.Some asymmetry in -863 CC vs. AA (A) and -863 AA vs. CA+CC (A). After one study removed, the publication bias was eliminated. See -863 CC vs. AA (B) and -863 AA vs. CA+CC (B).
Mentions: Begg's funnel plot and Egger's test were performed to access the publication bias of the studies. No evidence of publication bias showed in -308 G allele vs. A allele or -308 GG vs. AA model (funnel plot data not show, Egger's test p = 0.470 and 0.556,respectively). However, funnel plot showed some asymmetry in -863 CC vs. AA and -863 AA vs. CA+CC models(Fig 4) and Egger's proved the existence of publication in these two models(p = 0.041 and 0.038, respectively). We excluded one study from the meta-analysis to see whether the publication bias still presented. The results showed that after the exclusion of study Chen, D. Q. et al [6], the publication bias was eliminated(funnel plot showed in Fig 4, Egger's test -863 CC vs. AA:p = 0.785; -863 AA vs. CA+CC:p = 0.541),and the conclusion still stable(-863 CC vs. AA: OR, 0.42; 95% CI, [0.23, 0.77]; p = 0.005; -863 AA vs. CA+CC: OR, 2.44; 95% CI, [1.34, 4.45]; p = 0.003).

Bottom Line: The data showed that TNF-<alpha>-863 CC genotype was significantly associated with HBV clearance (-863 CC vs.For the other polymorphisms, no association with HBV infection outcome was found.Furthermore, ethnicity might play an important role in HBV infection outcome, leading to conflicting results.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Infectious Disease Diagnosis and Treatment, College of Medicine, First Affiliated Hospital, Zhejiang University, Zhejiang, China.

ABSTRACT

Background: The clearance of hepatitis B virus (HBV) is a complex process which may be influenced by many factors including polymorphisms in the tumor necrosis factor (TNF-) gene promoter. However, previous reports regarding the relationship between polymorphisms in the TNF- promoter and HBV clearance have been inconsistent. Therefore, we performed a meta-analysis on a large population to address this inconsistency.

Methods: A meta-analysis was performed to examine the association between TNF- promoter polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A and-238G/A) and chronic hepatitis B infection. Odds ratio (OR) and its 95 % confidence interval (CI) were used.

Results: Twelve studies were chosen in our meta-analysis, involving 2,754 chronic HBV infection cases and 1,630 HBV clearance cases. The data showed that TNF--863 CC genotype was significantly associated with HBV clearance (-863 CC vs. AA: OR, 0.64; 95% CI, [0.42, 0.97]; p = 0.04) while patients carrying -308 GG genotype had a significantly increased risk of HBV persistence compared with those with GA or AA genotype (GG vs. GA+AA: OR, 1.35; 95% CI, [1.08, 1.70]; p = 0.01). For the other polymorphisms, no association with HBV infection outcome was found.

Conclusions: The data showed that polymorphisms -863 A and -308 G in the TNF- gene promoter region might be risk factors for HBV persistence. Furthermore, ethnicity might play an important role in HBV infection outcome, leading to conflicting results. More studies on individuals from various ethnic groups will be necessary to determine the role of TNF- promoter polymorphisms in the outcome of HBV infection.

Show MeSH
Related in: MedlinePlus