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Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.

Maeder P, Bracoud L, Chabriat H, Gass A, Michel P, Hennerici M - J. Neurol. (2010)

Bottom Line: A total of 1,056 patients (men and women ≥ 55 years) were included.The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection.This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

View Article: PubMed Central - PubMed

Affiliation: Centre Hospitalier Universitaire Vaudois, Service de Radiologie, Lausanne, Switzerland. philippe.maeder@chuv.ch

ABSTRACT
Quantitative information from magnetic resonance imaging (MRI) may substantiate clinical findings and provide additional insight into the mechanism of clinical interventions in therapeutic stroke trials. The PERFORM study is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke. We report on the design of an exploratory longitudinal MRI follow-up study that was performed in a subgroup of the PERFORM trial. An international multi-centre longitudinal follow-up MRI study was designed for different MR systems employing safety and efficacy readouts: new T2 lesions, new DWI lesions, whole brain volume change, hippocampal volume change, changes in tissue microstructure as depicted by mean diffusivity and fractional anisotropy, vessel patency on MR angiography, and the presence of and development of new microbleeds. A total of 1,056 patients (men and women ≥ 55 years) were included. The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection. This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

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Related in: MedlinePlus

Intracranial cavity detection. The T2* sequence was used to detect the intracranial cavity contours (in red) as it clearly depicts external CSF (left). Given the lack of full brain coverage for all patients the 3DT1 sequence was automatically coregistered to T2*, resliced in the axial plane, and used to manually complete for potentially missing upper and lower slices (right)
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Fig5: Intracranial cavity detection. The T2* sequence was used to detect the intracranial cavity contours (in red) as it clearly depicts external CSF (left). Given the lack of full brain coverage for all patients the 3DT1 sequence was automatically coregistered to T2*, resliced in the axial plane, and used to manually complete for potentially missing upper and lower slices (right)

Mentions: The volume of the intracranial cavity was used to normalize the different volumetric measurements. The T2* sequence was used for this purpose as it clearly depicts external CSF. Given that the full brain coverage could not be achieved for all patients (24–28 slices of 5 mm were used), the 3DT1 sequence was automatically coregistered to T2* and used to manually complete for potentially missing upper and lower slices, and correct for T2*-related artifacts (Fig. 5).Fig. 5


Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.

Maeder P, Bracoud L, Chabriat H, Gass A, Michel P, Hennerici M - J. Neurol. (2010)

Intracranial cavity detection. The T2* sequence was used to detect the intracranial cavity contours (in red) as it clearly depicts external CSF (left). Given the lack of full brain coverage for all patients the 3DT1 sequence was automatically coregistered to T2*, resliced in the axial plane, and used to manually complete for potentially missing upper and lower slices (right)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3090565&req=5

Fig5: Intracranial cavity detection. The T2* sequence was used to detect the intracranial cavity contours (in red) as it clearly depicts external CSF (left). Given the lack of full brain coverage for all patients the 3DT1 sequence was automatically coregistered to T2*, resliced in the axial plane, and used to manually complete for potentially missing upper and lower slices (right)
Mentions: The volume of the intracranial cavity was used to normalize the different volumetric measurements. The T2* sequence was used for this purpose as it clearly depicts external CSF. Given that the full brain coverage could not be achieved for all patients (24–28 slices of 5 mm were used), the 3DT1 sequence was automatically coregistered to T2* and used to manually complete for potentially missing upper and lower slices, and correct for T2*-related artifacts (Fig. 5).Fig. 5

Bottom Line: A total of 1,056 patients (men and women ≥ 55 years) were included.The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection.This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

View Article: PubMed Central - PubMed

Affiliation: Centre Hospitalier Universitaire Vaudois, Service de Radiologie, Lausanne, Switzerland. philippe.maeder@chuv.ch

ABSTRACT
Quantitative information from magnetic resonance imaging (MRI) may substantiate clinical findings and provide additional insight into the mechanism of clinical interventions in therapeutic stroke trials. The PERFORM study is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke. We report on the design of an exploratory longitudinal MRI follow-up study that was performed in a subgroup of the PERFORM trial. An international multi-centre longitudinal follow-up MRI study was designed for different MR systems employing safety and efficacy readouts: new T2 lesions, new DWI lesions, whole brain volume change, hippocampal volume change, changes in tissue microstructure as depicted by mean diffusivity and fractional anisotropy, vessel patency on MR angiography, and the presence of and development of new microbleeds. A total of 1,056 patients (men and women ≥ 55 years) were included. The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection. This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

Show MeSH
Related in: MedlinePlus