Limits...
Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.

Maeder P, Bracoud L, Chabriat H, Gass A, Michel P, Hennerici M - J. Neurol. (2010)

Bottom Line: A total of 1,056 patients (men and women ≥ 55 years) were included.The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection.This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

View Article: PubMed Central - PubMed

Affiliation: Centre Hospitalier Universitaire Vaudois, Service de Radiologie, Lausanne, Switzerland. philippe.maeder@chuv.ch

ABSTRACT
Quantitative information from magnetic resonance imaging (MRI) may substantiate clinical findings and provide additional insight into the mechanism of clinical interventions in therapeutic stroke trials. The PERFORM study is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke. We report on the design of an exploratory longitudinal MRI follow-up study that was performed in a subgroup of the PERFORM trial. An international multi-centre longitudinal follow-up MRI study was designed for different MR systems employing safety and efficacy readouts: new T2 lesions, new DWI lesions, whole brain volume change, hippocampal volume change, changes in tissue microstructure as depicted by mean diffusivity and fractional anisotropy, vessel patency on MR angiography, and the presence of and development of new microbleeds. A total of 1,056 patients (men and women ≥ 55 years) were included. The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection. This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

Show MeSH

Related in: MedlinePlus

Lesion detection. From left to right, hyperintense FLAIR lesions, hypointense FLAIR lesions, and hyperintense DWI lesions were pre-detected using an unsupervised 3D segmentation algorithm after skull removal, and manually validated prior to submission to readers
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3090565&req=5

Fig2: Lesion detection. From left to right, hyperintense FLAIR lesions, hypointense FLAIR lesions, and hyperintense DWI lesions were pre-detected using an unsupervised 3D segmentation algorithm after skull removal, and manually validated prior to submission to readers

Mentions: Hyperintense FLAIR lesions, hypointense FLAIR lesions and hyperintense DWI lesions were pre-detected using an unsupervised 3D segmentation algorithm on FLAIR and DWI isotropic images after skull removal, and manually validated prior to submission to the readers (Fig. 2).Fig. 2


Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.

Maeder P, Bracoud L, Chabriat H, Gass A, Michel P, Hennerici M - J. Neurol. (2010)

Lesion detection. From left to right, hyperintense FLAIR lesions, hypointense FLAIR lesions, and hyperintense DWI lesions were pre-detected using an unsupervised 3D segmentation algorithm after skull removal, and manually validated prior to submission to readers
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3090565&req=5

Fig2: Lesion detection. From left to right, hyperintense FLAIR lesions, hypointense FLAIR lesions, and hyperintense DWI lesions were pre-detected using an unsupervised 3D segmentation algorithm after skull removal, and manually validated prior to submission to readers
Mentions: Hyperintense FLAIR lesions, hypointense FLAIR lesions and hyperintense DWI lesions were pre-detected using an unsupervised 3D segmentation algorithm on FLAIR and DWI isotropic images after skull removal, and manually validated prior to submission to the readers (Fig. 2).Fig. 2

Bottom Line: A total of 1,056 patients (men and women ≥ 55 years) were included.The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection.This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

View Article: PubMed Central - PubMed

Affiliation: Centre Hospitalier Universitaire Vaudois, Service de Radiologie, Lausanne, Switzerland. philippe.maeder@chuv.ch

ABSTRACT
Quantitative information from magnetic resonance imaging (MRI) may substantiate clinical findings and provide additional insight into the mechanism of clinical interventions in therapeutic stroke trials. The PERFORM study is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke. We report on the design of an exploratory longitudinal MRI follow-up study that was performed in a subgroup of the PERFORM trial. An international multi-centre longitudinal follow-up MRI study was designed for different MR systems employing safety and efficacy readouts: new T2 lesions, new DWI lesions, whole brain volume change, hippocampal volume change, changes in tissue microstructure as depicted by mean diffusivity and fractional anisotropy, vessel patency on MR angiography, and the presence of and development of new microbleeds. A total of 1,056 patients (men and women ≥ 55 years) were included. The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection. This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients.

Show MeSH
Related in: MedlinePlus