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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma).

Scheja A, Akesson A, Geborek P, Wildt M, Wollheim CB, Wollheim FA, Vischer UM - Arthritis Res. (2001)

Bottom Line: In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups.A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident.Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rheumatology, University Hospital, Lund, Sweden.

ABSTRACT
In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

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Plasma levels of vWf and its propeptide in 44 patients with SSc, grouped according to the degree of skin involvement. Medians are marked with horizontal bars.
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Figure 1: Plasma levels of vWf and its propeptide in 44 patients with SSc, grouped according to the degree of skin involvement. Medians are marked with horizontal bars.

Mentions: Plasma concentrations of vWf in 44 SSc patients were higher than the corresponding concentrations of propeptide (P < 0.01; Supplementary Fig. 1). One outlier in vWf, with a plasma concentration nearly three times higher than any other observation, was excluded from all calculations. The range of propeptide values in each patient subgroup was narrower than that for vWf. The three subgroups (dSSc, lSSc, and suspSSc) differed in vWf (P < 0.05) but not in propeptide (P = 0.11). There was a correlation between vWf and propeptide (rho = 0.36, P < 0.05).


Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma).

Scheja A, Akesson A, Geborek P, Wildt M, Wollheim CB, Wollheim FA, Vischer UM - Arthritis Res. (2001)

Plasma levels of vWf and its propeptide in 44 patients with SSc, grouped according to the degree of skin involvement. Medians are marked with horizontal bars.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC30710&req=5

Figure 1: Plasma levels of vWf and its propeptide in 44 patients with SSc, grouped according to the degree of skin involvement. Medians are marked with horizontal bars.
Mentions: Plasma concentrations of vWf in 44 SSc patients were higher than the corresponding concentrations of propeptide (P < 0.01; Supplementary Fig. 1). One outlier in vWf, with a plasma concentration nearly three times higher than any other observation, was excluded from all calculations. The range of propeptide values in each patient subgroup was narrower than that for vWf. The three subgroups (dSSc, lSSc, and suspSSc) differed in vWf (P < 0.05) but not in propeptide (P = 0.11). There was a correlation between vWf and propeptide (rho = 0.36, P < 0.05).

Bottom Line: In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups.A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident.Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Rheumatology, University Hospital, Lund, Sweden.

ABSTRACT
In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

Show MeSH
Related in: MedlinePlus