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Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.

Kittiniyom K, Gorse KM, Dalbegue F, Lichy JH, Taubenberger JK, Newsham IF - Breast Cancer Res. (2001)

Bottom Line: Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ.When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated.These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Virginia Commonweath University, Richmond, USA.

ABSTRACT
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

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Other LOH in tumors with chromosome 18p allelic deletion.
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Figure 3: Other LOH in tumors with chromosome 18p allelic deletion.

Mentions: Realizing that loss on 18p is only one part of the complex genetic profile for breast cancer, we sought to discover whether genetic alteration on this chromosome correlated with LOH in other regions known to undergo allelic deletion in cancer. These tumors had previously been shown to have undergone allelic deletion on chromosomes 3p (77%), 9p (75%), 11p (37%), 13q (39%), 16q (85%), 17p (100%) and 17q (71%). The LOH results specifically for those tumors also showing detectable chromosome 18p LOH are presented in Figure 3. In every instance where information was available, LOH on chromosomes 3p (region C13-CA373-D3S1300), 9p (region D9S171-D9S1748), 17p (region D17S1832-D17S1788 including p53) and 17q (region THRA1-D17S928 including nm23) was present when 18p LOH occurred. Chromosome 16q LOH (region D16S496-D16S513), in contrast, was only found in 81%, chromosome 13q (D13S260-D13S263) in 55%, and chromosome 11p (region D11S922-D11S988 including TH) in 48% of tumors also having 18p LOH. These frequencies suggest that alterations on chromosome 18p occur more often in the presence of alterations affecting regions containing such tumor suppressors as p16 (9p) [17] and p53 (17p) [18], while events on chromosomes 13q, 16q and 11p occur more independently.


Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.

Kittiniyom K, Gorse KM, Dalbegue F, Lichy JH, Taubenberger JK, Newsham IF - Breast Cancer Res. (2001)

Other LOH in tumors with chromosome 18p allelic deletion.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC30703&req=5

Figure 3: Other LOH in tumors with chromosome 18p allelic deletion.
Mentions: Realizing that loss on 18p is only one part of the complex genetic profile for breast cancer, we sought to discover whether genetic alteration on this chromosome correlated with LOH in other regions known to undergo allelic deletion in cancer. These tumors had previously been shown to have undergone allelic deletion on chromosomes 3p (77%), 9p (75%), 11p (37%), 13q (39%), 16q (85%), 17p (100%) and 17q (71%). The LOH results specifically for those tumors also showing detectable chromosome 18p LOH are presented in Figure 3. In every instance where information was available, LOH on chromosomes 3p (region C13-CA373-D3S1300), 9p (region D9S171-D9S1748), 17p (region D17S1832-D17S1788 including p53) and 17q (region THRA1-D17S928 including nm23) was present when 18p LOH occurred. Chromosome 16q LOH (region D16S496-D16S513), in contrast, was only found in 81%, chromosome 13q (D13S260-D13S263) in 55%, and chromosome 11p (region D11S922-D11S988 including TH) in 48% of tumors also having 18p LOH. These frequencies suggest that alterations on chromosome 18p occur more often in the presence of alterations affecting regions containing such tumor suppressors as p16 (9p) [17] and p53 (17p) [18], while events on chromosomes 13q, 16q and 11p occur more independently.

Bottom Line: Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ.When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated.These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Virginia Commonweath University, Richmond, USA.

ABSTRACT
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

Show MeSH
Related in: MedlinePlus