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Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.

Kittiniyom K, Gorse KM, Dalbegue F, Lichy JH, Taubenberger JK, Newsham IF - Breast Cancer Res. (2001)

Bottom Line: Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ.When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated.These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Virginia Commonweath University, Richmond, USA.

ABSTRACT
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

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Schematic representation of 18p LOH in all stages of breast carcinoma. Tumor sample numbers are listed on the left. Analysis at markers D18S59, D18S481 and D18S452 are shown for all DCIS, IDC and metastases studied.
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Figure 1: Schematic representation of 18p LOH in all stages of breast carcinoma. Tumor sample numbers are listed on the left. Analysis at markers D18S59, D18S481 and D18S452 are shown for all DCIS, IDC and metastases studied.

Mentions: A total of 96 foci were analyzed for LOH at several polymorphic markers in 18p11.3. The overall frequency of LOH in 18p11.3 was 63% (27/43). When analyzed by tumor stage, LOH on 18p was found in 56% (9/16) of ductal carcinoma in situ (DCIS) foci, 67% of invasive ductal carcinoma (IDC) foci (14/21), and 67% (4/6) of metastatic disease. A schematic diagram of these results appears in Figure 1.


Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.

Kittiniyom K, Gorse KM, Dalbegue F, Lichy JH, Taubenberger JK, Newsham IF - Breast Cancer Res. (2001)

Schematic representation of 18p LOH in all stages of breast carcinoma. Tumor sample numbers are listed on the left. Analysis at markers D18S59, D18S481 and D18S452 are shown for all DCIS, IDC and metastases studied.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC30703&req=5

Figure 1: Schematic representation of 18p LOH in all stages of breast carcinoma. Tumor sample numbers are listed on the left. Analysis at markers D18S59, D18S481 and D18S452 are shown for all DCIS, IDC and metastases studied.
Mentions: A total of 96 foci were analyzed for LOH at several polymorphic markers in 18p11.3. The overall frequency of LOH in 18p11.3 was 63% (27/43). When analyzed by tumor stage, LOH on 18p was found in 56% (9/16) of ductal carcinoma in situ (DCIS) foci, 67% of invasive ductal carcinoma (IDC) foci (14/21), and 67% (4/6) of metastatic disease. A schematic diagram of these results appears in Figure 1.

Bottom Line: Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ.When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated.These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Virginia Commonweath University, Richmond, USA.

ABSTRACT
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.

Show MeSH
Related in: MedlinePlus