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Safety and efficacy of intratracheal DNase with physiotherapy in severe status asthmaticus

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Since 2004, we have used intratracheal DNase with physiotherapy as second-line therapy in mechanically ventilated children with severe status asthmatics who are refractory to conventional medical management... Forty-six ventilated children, median (IQR) age 74 months (45 to 141), received intratracheal DNase with physiotherapy (January 2004 to August 2010)... The median (IQR) time to DNase following PICU admission was 2.1 hours (1.3 to 3.8)... Overall DNase produced an improvement in ventilation (see Figure 1)... Salbutamol IV was constant at 1 μg/kg/minute (0.5 to 2)... The therapy was well tolerated with no hypoxic or hypotensive episodes, or air leaks... Median length of ventilation was 22 hours (15 to 37)... No patient required extracorporeal membrane oxygenation and there were no deaths... Intratracheal DNase with physiotherapy is safe and effective therapy for refractory ventilated patients with status asthmatics.

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Fractional polynomial regression of PIP/PCO2 following DNAse.
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Figure 1: Fractional polynomial regression of PIP/PCO2 following DNAse.

Mentions: The median (IQR) time to DNase following PICU admission was 2.1 hours (1.3 to 3.8). At the time of DNase, median PIP was 34 cm (30 to 40), pH was 7.12 (7.01 to 7.22) and pCO2 was 11 kPa (7.9 to 14.1). Overall DNase produced an improvement in ventilation (see Figure 1). Salbutamol IV was constant at 1 μg/kg/minute (0.5 to 2). The therapy was well tolerated with no hypoxic or hypotensive episodes, or air leaks. Median length of ventilation was 22 hours (15 to 37). No patient required extracorporeal membrane oxygenation and there were no deaths.


Safety and efficacy of intratracheal DNase with physiotherapy in severe status asthmaticus
Fractional polynomial regression of PIP/PCO2 following DNAse.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3066859&req=5

Figure 1: Fractional polynomial regression of PIP/PCO2 following DNAse.
Mentions: The median (IQR) time to DNase following PICU admission was 2.1 hours (1.3 to 3.8). At the time of DNase, median PIP was 34 cm (30 to 40), pH was 7.12 (7.01 to 7.22) and pCO2 was 11 kPa (7.9 to 14.1). Overall DNase produced an improvement in ventilation (see Figure 1). Salbutamol IV was constant at 1 μg/kg/minute (0.5 to 2). The therapy was well tolerated with no hypoxic or hypotensive episodes, or air leaks. Median length of ventilation was 22 hours (15 to 37). No patient required extracorporeal membrane oxygenation and there were no deaths.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Since 2004, we have used intratracheal DNase with physiotherapy as second-line therapy in mechanically ventilated children with severe status asthmatics who are refractory to conventional medical management... Forty-six ventilated children, median (IQR) age 74 months (45 to 141), received intratracheal DNase with physiotherapy (January 2004 to August 2010)... The median (IQR) time to DNase following PICU admission was 2.1 hours (1.3 to 3.8)... Overall DNase produced an improvement in ventilation (see Figure 1)... Salbutamol IV was constant at 1 μg/kg/minute (0.5 to 2)... The therapy was well tolerated with no hypoxic or hypotensive episodes, or air leaks... Median length of ventilation was 22 hours (15 to 37)... No patient required extracorporeal membrane oxygenation and there were no deaths... Intratracheal DNase with physiotherapy is safe and effective therapy for refractory ventilated patients with status asthmatics.

No MeSH data available.


Related in: MedlinePlus