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Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice.

Sharma A, Sharma V, Kansal L - Libyan J Med (2010)

Bottom Line: Lead nitrate exposure also produced detrimental effects on the redox status of the liver indicated by a significant decline in the levels of liver antioxidants such as superoxide dismutase, catalase, and glutathione.Histological examination of the liver also revealed pathophysiological changes in lead nitrate-exposed group and treatment with garlic improved liver histology.Our data suggest that garlic is a phytoantioxidant that can counteract the deleterious effects of lead nitrate.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India.

ABSTRACT
Lead is a blue-gray and highly toxic divalent metal that occurs naturally in the earth's crust and is spread throughout the environment by various human activities. The efficacy of garlic (Allium sativum) to reduce hepatotoxicity induced by lead nitrate was evaluated experimentally in male mice. Oral treatment with lead nitrate at a dose of 50 mg/kg body weight daily for 40 days (1/45 of LD(50)) induced a significant increase in the levels of hepatic aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acid phosphatase, cholesterol, lipid peroxidation, and lead nitrate. In parallel, hepatic protein levels in lead-exposed mice were significantly depleted. Lead nitrate exposure also produced detrimental effects on the redox status of the liver indicated by a significant decline in the levels of liver antioxidants such as superoxide dismutase, catalase, and glutathione. After exposure to lead nitrate (50 mg/kg body weight for 10 days), the animals received aqueous garlic extract (250 mg/kg body weight and 500 mg/kg body weight) and ethanolic garlic extract (100 mg/kg body weight and 250 mg/kg body weight), and partially restored the deranged parameters significantly. Histological examination of the liver also revealed pathophysiological changes in lead nitrate-exposed group and treatment with garlic improved liver histology. Our data suggest that garlic is a phytoantioxidant that can counteract the deleterious effects of lead nitrate.

No MeSH data available.


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Liver section obtained from a mouse after treatment with lead nitrate and garlic showing improvement of hepatic tissue.
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Figure 0004: Liver section obtained from a mouse after treatment with lead nitrate and garlic showing improvement of hepatic tissue.

Mentions: In the high dose groups (Groups 4 and 6), the liver restored most of its normal structure and was able to diminish the fibrosis, congestion, incidence of inflammatory cells infiltration, centrilobular hepatocytes swelling, hepatocytes vacuolization, fatty changes, and hemorrhagic clots (Fig. 4).


Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice.

Sharma A, Sharma V, Kansal L - Libyan J Med (2010)

Liver section obtained from a mouse after treatment with lead nitrate and garlic showing improvement of hepatic tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3066784&req=5

Figure 0004: Liver section obtained from a mouse after treatment with lead nitrate and garlic showing improvement of hepatic tissue.
Mentions: In the high dose groups (Groups 4 and 6), the liver restored most of its normal structure and was able to diminish the fibrosis, congestion, incidence of inflammatory cells infiltration, centrilobular hepatocytes swelling, hepatocytes vacuolization, fatty changes, and hemorrhagic clots (Fig. 4).

Bottom Line: Lead nitrate exposure also produced detrimental effects on the redox status of the liver indicated by a significant decline in the levels of liver antioxidants such as superoxide dismutase, catalase, and glutathione.Histological examination of the liver also revealed pathophysiological changes in lead nitrate-exposed group and treatment with garlic improved liver histology.Our data suggest that garlic is a phytoantioxidant that can counteract the deleterious effects of lead nitrate.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India.

ABSTRACT
Lead is a blue-gray and highly toxic divalent metal that occurs naturally in the earth's crust and is spread throughout the environment by various human activities. The efficacy of garlic (Allium sativum) to reduce hepatotoxicity induced by lead nitrate was evaluated experimentally in male mice. Oral treatment with lead nitrate at a dose of 50 mg/kg body weight daily for 40 days (1/45 of LD(50)) induced a significant increase in the levels of hepatic aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acid phosphatase, cholesterol, lipid peroxidation, and lead nitrate. In parallel, hepatic protein levels in lead-exposed mice were significantly depleted. Lead nitrate exposure also produced detrimental effects on the redox status of the liver indicated by a significant decline in the levels of liver antioxidants such as superoxide dismutase, catalase, and glutathione. After exposure to lead nitrate (50 mg/kg body weight for 10 days), the animals received aqueous garlic extract (250 mg/kg body weight and 500 mg/kg body weight) and ethanolic garlic extract (100 mg/kg body weight and 250 mg/kg body weight), and partially restored the deranged parameters significantly. Histological examination of the liver also revealed pathophysiological changes in lead nitrate-exposed group and treatment with garlic improved liver histology. Our data suggest that garlic is a phytoantioxidant that can counteract the deleterious effects of lead nitrate.

No MeSH data available.


Related in: MedlinePlus