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Prevalence of Gall Bladder Stones among Type 2 Diabetic Patients in Benghazi Libya: A Case-control Study.

Elmehdawi R, Elmajberi S, Behieh A, Elramli A - Libyan J Med (2009)

Bottom Line: Increasing age, female gender, overweight, familial history of the disease and type 2 diabetes mellitus is all associated with an increased risk of gallstones.Females were significantly more affected than males.Libyan diabetic patients with gallstones tend to be older and more obese than those without gallstones.

View Article: PubMed Central - PubMed

Affiliation: Department of internal medicine, Al-Arab medical University.

ABSTRACT

Background: Diabetes mellitus and gall bladder stones are both common and costly diseases. Increasing age, female gender, overweight, familial history of the disease and type 2 diabetes mellitus is all associated with an increased risk of gallstones. Several studies from around the world reported an increased prevalence of gall bladder stones in patients with diabetes mellitus.

Aims and objectives: The aim of this study was to define the frequency of gall bladder stones among Libyan diabetics and to evaluate the possible associated risk factors in these patients.

Patients and methods: A case-control study was performed during 2007 at Benghazi Diabetes and endocrinology Center. The study involved 161 randomly selected type-2 diabetic patients under regular follow up at the center, and 166 age and sex matched non-diabetic outpatients at the 7th of October teaching hospital. Real-time abdominal ultrasound was performed by two radiologists to examine the abdomen after an overnight fast.

Results: About 40% of the diabetic cohort had gall bladder stones as compared to 17.5% of non-diabetic patients. Females were significantly more affected than males. Patients with gall bladder stones were significantly older and had a significantly higher body mass index than those without stones.

Conclusion: The prevalence of gallstones in Libyan diabetic patients is higher than the rates reported in other parts of the world. Libyan diabetic patients with gallstones tend to be older and more obese than those without gallstones. Duration of diabetes mellitus and type of treatment does not seem to influence the frequency of gall bladder stones among Libyan diabetics.

No MeSH data available.


Related in: MedlinePlus

frequency of GBS among type-2 diabetics according to BMI
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Figure 0002: frequency of GBS among type-2 diabetics according to BMI

Mentions: The mean BMI for diabetics with GBS was significantly higher, 34.78+/−6.29, than the mean BMI for diabetics without GBS, 32.2+/−7.5, (p = 0.027). Risk of GBS increased significantly when BMI was over 24 kg/m2 (p = 0.019) (Figure 2). Moreover, the mean BMI of diabetic females with GBS was significantly higher than the mean BMI of diabetic males with GBS (p <0.001). A family history of GBS was found in 40.6% of patients with GBS and 27.8% of those without, but it was only in females that the difference (48% vs. 24.5%) was significant (p = 0.011). The frequency of GBS progressively increased with number of pregnancies (Figure 3). About 50.5% of multiparus females had GBS as compared to 10% of iparus (p = 0.01). Mean parity of females with GBS (10.1+/−3.48; range: 0–17) was significantly higher (p = 0.010) than mean parity of females without GBS (7.7+/−4.7; range: 0–17). About 44% of females with GBS were using oral contraceptives as compared to 42% of females without GBS (p = 0.84, both groups had almost the same mean age, mean duration of DM and mean BMI).


Prevalence of Gall Bladder Stones among Type 2 Diabetic Patients in Benghazi Libya: A Case-control Study.

Elmehdawi R, Elmajberi S, Behieh A, Elramli A - Libyan J Med (2009)

frequency of GBS among type-2 diabetics according to BMI
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3066708&req=5

Figure 0002: frequency of GBS among type-2 diabetics according to BMI
Mentions: The mean BMI for diabetics with GBS was significantly higher, 34.78+/−6.29, than the mean BMI for diabetics without GBS, 32.2+/−7.5, (p = 0.027). Risk of GBS increased significantly when BMI was over 24 kg/m2 (p = 0.019) (Figure 2). Moreover, the mean BMI of diabetic females with GBS was significantly higher than the mean BMI of diabetic males with GBS (p <0.001). A family history of GBS was found in 40.6% of patients with GBS and 27.8% of those without, but it was only in females that the difference (48% vs. 24.5%) was significant (p = 0.011). The frequency of GBS progressively increased with number of pregnancies (Figure 3). About 50.5% of multiparus females had GBS as compared to 10% of iparus (p = 0.01). Mean parity of females with GBS (10.1+/−3.48; range: 0–17) was significantly higher (p = 0.010) than mean parity of females without GBS (7.7+/−4.7; range: 0–17). About 44% of females with GBS were using oral contraceptives as compared to 42% of females without GBS (p = 0.84, both groups had almost the same mean age, mean duration of DM and mean BMI).

Bottom Line: Increasing age, female gender, overweight, familial history of the disease and type 2 diabetes mellitus is all associated with an increased risk of gallstones.Females were significantly more affected than males.Libyan diabetic patients with gallstones tend to be older and more obese than those without gallstones.

View Article: PubMed Central - PubMed

Affiliation: Department of internal medicine, Al-Arab medical University.

ABSTRACT

Background: Diabetes mellitus and gall bladder stones are both common and costly diseases. Increasing age, female gender, overweight, familial history of the disease and type 2 diabetes mellitus is all associated with an increased risk of gallstones. Several studies from around the world reported an increased prevalence of gall bladder stones in patients with diabetes mellitus.

Aims and objectives: The aim of this study was to define the frequency of gall bladder stones among Libyan diabetics and to evaluate the possible associated risk factors in these patients.

Patients and methods: A case-control study was performed during 2007 at Benghazi Diabetes and endocrinology Center. The study involved 161 randomly selected type-2 diabetic patients under regular follow up at the center, and 166 age and sex matched non-diabetic outpatients at the 7th of October teaching hospital. Real-time abdominal ultrasound was performed by two radiologists to examine the abdomen after an overnight fast.

Results: About 40% of the diabetic cohort had gall bladder stones as compared to 17.5% of non-diabetic patients. Females were significantly more affected than males. Patients with gall bladder stones were significantly older and had a significantly higher body mass index than those without stones.

Conclusion: The prevalence of gallstones in Libyan diabetic patients is higher than the rates reported in other parts of the world. Libyan diabetic patients with gallstones tend to be older and more obese than those without gallstones. Duration of diabetes mellitus and type of treatment does not seem to influence the frequency of gall bladder stones among Libyan diabetics.

No MeSH data available.


Related in: MedlinePlus