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Liposomes for use in gene delivery.

Balazs DA, Godbey W - J Drug Deliv (2010)

Bottom Line: Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures.These arrangements can be found in many shapes and sizes depending on lipid composition.Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Gene Therapy and Cellular Engineering, Department of Chemical and Biomolecular Engineering, Tulane University, 6823 St. Charles Avenue, 300 Lindy Boggs Center, New Orleans, LA 70118, USA.

ABSTRACT
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.

No MeSH data available.


The structure of DOSPA.
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Related In: Results  -  Collection


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fig6: The structure of DOSPA.

Mentions: In contrast to cationic liposomes containing fully charged quaternary amines (e.g. DOTMA and DOTAP), DC-Chol, in a 1 : 1 lipid ratio with DOPE, contains a tertiary amine that is charged on 50% of the liposome surface at pH 7.4 [45]. This feature is thought to reduce the aggregation of lipoplexes leading to higher transgene expression [46]. The reduction in overall lipoplex charge can also aid in DNA dissociation during gene delivery [41], which has been proven to be necessary for successful transfection [42].


Liposomes for use in gene delivery.

Balazs DA, Godbey W - J Drug Deliv (2010)

The structure of DOSPA.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3066571&req=5

fig6: The structure of DOSPA.
Mentions: In contrast to cationic liposomes containing fully charged quaternary amines (e.g. DOTMA and DOTAP), DC-Chol, in a 1 : 1 lipid ratio with DOPE, contains a tertiary amine that is charged on 50% of the liposome surface at pH 7.4 [45]. This feature is thought to reduce the aggregation of lipoplexes leading to higher transgene expression [46]. The reduction in overall lipoplex charge can also aid in DNA dissociation during gene delivery [41], which has been proven to be necessary for successful transfection [42].

Bottom Line: Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures.These arrangements can be found in many shapes and sizes depending on lipid composition.Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Gene Therapy and Cellular Engineering, Department of Chemical and Biomolecular Engineering, Tulane University, 6823 St. Charles Avenue, 300 Lindy Boggs Center, New Orleans, LA 70118, USA.

ABSTRACT
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.

No MeSH data available.