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Liposomes for use in gene delivery.

Balazs DA, Godbey W - J Drug Deliv (2010)

Bottom Line: Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures.These arrangements can be found in many shapes and sizes depending on lipid composition.Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Gene Therapy and Cellular Engineering, Department of Chemical and Biomolecular Engineering, Tulane University, 6823 St. Charles Avenue, 300 Lindy Boggs Center, New Orleans, LA 70118, USA.

ABSTRACT
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.

No MeSH data available.


Certain amphipathic lipid molecules in aqueous solution spontaneously form leaflets, then bilayer membranes, and eventually liposomes.
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Related In: Results  -  Collection


getmorefigures.php?uid=PMC3066571&req=5

fig1: Certain amphipathic lipid molecules in aqueous solution spontaneously form leaflets, then bilayer membranes, and eventually liposomes.

Mentions: Liposomes are generally formed by the self-assembly of dissolved lipid molecules, each of which contains a hydrophilic head group and hydrophobic tails. These lipids take on associations which yield entropically favorable states of low free energy, in some cases forming bimolecular lipid leaflets (Figure 1). Such leaflets are characterized by hydrophobic hydrocarbon tails facing each other and hydrophilic head groups facing outward to associate with aqueous solution [9]. At this point, the bilayer formation is still energetically unfavorable because the hydrophobic parts of the molecules are still in contact with water, a problem that is overcome through curvature of the forming bilayer membrane upon itself to form a vesicle with closed edges [10] (Figure 1). This free-energy-driven self-assembly is stable and has been exploited as a powerful mechanism for engineering liposomes specifically to the needs of a given system [11].


Liposomes for use in gene delivery.

Balazs DA, Godbey W - J Drug Deliv (2010)

Certain amphipathic lipid molecules in aqueous solution spontaneously form leaflets, then bilayer membranes, and eventually liposomes.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3066571&req=5

fig1: Certain amphipathic lipid molecules in aqueous solution spontaneously form leaflets, then bilayer membranes, and eventually liposomes.
Mentions: Liposomes are generally formed by the self-assembly of dissolved lipid molecules, each of which contains a hydrophilic head group and hydrophobic tails. These lipids take on associations which yield entropically favorable states of low free energy, in some cases forming bimolecular lipid leaflets (Figure 1). Such leaflets are characterized by hydrophobic hydrocarbon tails facing each other and hydrophilic head groups facing outward to associate with aqueous solution [9]. At this point, the bilayer formation is still energetically unfavorable because the hydrophobic parts of the molecules are still in contact with water, a problem that is overcome through curvature of the forming bilayer membrane upon itself to form a vesicle with closed edges [10] (Figure 1). This free-energy-driven self-assembly is stable and has been exploited as a powerful mechanism for engineering liposomes specifically to the needs of a given system [11].

Bottom Line: Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures.These arrangements can be found in many shapes and sizes depending on lipid composition.Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Gene Therapy and Cellular Engineering, Department of Chemical and Biomolecular Engineering, Tulane University, 6823 St. Charles Avenue, 300 Lindy Boggs Center, New Orleans, LA 70118, USA.

ABSTRACT
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.

No MeSH data available.