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Large-spot subthreshold transpupillary thermotherapy for chronic serous macular detachment.

Giudice GL, de Belvis V, Tavolato M, Galan A - Clin Ophthalmol (2011)

Bottom Line: The mean logarithm of the minimum angle of resolution best-corrected visual acuity was significantly better compared with baseline.Mean optical coherence tomography (OCT) central foveal thickness was significantly lower in all patients (P < 0.001) compared with pretreatment OCT, with a reduction in subretinal fluid and resolution of serous detachment associated with anatomical fovea restoration.The encouraging results and lack of visually significant complications suggest that further investigation is warranted.

View Article: PubMed Central - PubMed

Affiliation: San Paolo Ophthalmic Center, San Antonio Hospital, Padova, Italy;

ABSTRACT

Purpose: To report the effect of subthreshold transpupillary thermotherapy (TTT) in treating serous detachment of the neurosensory retina secondary to chronic central serous chorioretinopathy (CCSC).

Methods: Seven eyes from five patients with CCSC, persistent serous detachment of the neurosensory retina and a clinical course of between 12 and 60 months were treated. All eyes received large-spot TTT guided by indocyanine green angiography (ICGA). Subthreshold TTT was performed using an 810 nm diode laser with a spot size of 3.0 mm (power was set at 350 mW). Treatment was applied for 60 seconds to the areas of choroidal hyperfluorescence on ICGA.

Results: The mean number of TTT sessions was 1.4 ± 0.5. All eyes were followed up for at least 6 months (mean 9.6 ± 3.2 standard deviation; range 6-12 months). The mean logarithm of the minimum angle of resolution best-corrected visual acuity was significantly better compared with baseline. All TTT-treated eyes had stable or improved vision (P < 0.001). Mean optical coherence tomography (OCT) central foveal thickness was significantly lower in all patients (P < 0.001) compared with pretreatment OCT, with a reduction in subretinal fluid and resolution of serous detachment associated with anatomical fovea restoration. No patient had any treatment-related side effects.

Conclusion: Modified subthreshold TTT appears to have a beneficial effect in treating patients with CCSC and persistent neurosensory detachment. The encouraging results and lack of visually significant complications suggest that further investigation is warranted.

No MeSH data available.


Related in: MedlinePlus

The time course of the height of the foveal detachment in all study eyes. The height was measured by optical coherence tomography. In six cases, the foveal detachment decreased after transpupillary thermotherapy (TTT). The height was significantly lower at 3 and 6 months after treatment (P < 0.01).
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f2-opth-5-355: The time course of the height of the foveal detachment in all study eyes. The height was measured by optical coherence tomography. In six cases, the foveal detachment decreased after transpupillary thermotherapy (TTT). The height was significantly lower at 3 and 6 months after treatment (P < 0.01).

Mentions: One eye showed a decrease in the height of the neurosensory elevation, and two eyes did not show any sign of resolution. At months 3 and 6, the foveal detachment completely resolved in three of the five patients, corresponding to five of seven study eyes (P = <0.001). Foveal detachment decreased but remained unresolved in one eye, and one eye did not show any sign of change (Figure 2).


Large-spot subthreshold transpupillary thermotherapy for chronic serous macular detachment.

Giudice GL, de Belvis V, Tavolato M, Galan A - Clin Ophthalmol (2011)

The time course of the height of the foveal detachment in all study eyes. The height was measured by optical coherence tomography. In six cases, the foveal detachment decreased after transpupillary thermotherapy (TTT). The height was significantly lower at 3 and 6 months after treatment (P < 0.01).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065580&req=5

f2-opth-5-355: The time course of the height of the foveal detachment in all study eyes. The height was measured by optical coherence tomography. In six cases, the foveal detachment decreased after transpupillary thermotherapy (TTT). The height was significantly lower at 3 and 6 months after treatment (P < 0.01).
Mentions: One eye showed a decrease in the height of the neurosensory elevation, and two eyes did not show any sign of resolution. At months 3 and 6, the foveal detachment completely resolved in three of the five patients, corresponding to five of seven study eyes (P = <0.001). Foveal detachment decreased but remained unresolved in one eye, and one eye did not show any sign of change (Figure 2).

Bottom Line: The mean logarithm of the minimum angle of resolution best-corrected visual acuity was significantly better compared with baseline.Mean optical coherence tomography (OCT) central foveal thickness was significantly lower in all patients (P < 0.001) compared with pretreatment OCT, with a reduction in subretinal fluid and resolution of serous detachment associated with anatomical fovea restoration.The encouraging results and lack of visually significant complications suggest that further investigation is warranted.

View Article: PubMed Central - PubMed

Affiliation: San Paolo Ophthalmic Center, San Antonio Hospital, Padova, Italy;

ABSTRACT

Purpose: To report the effect of subthreshold transpupillary thermotherapy (TTT) in treating serous detachment of the neurosensory retina secondary to chronic central serous chorioretinopathy (CCSC).

Methods: Seven eyes from five patients with CCSC, persistent serous detachment of the neurosensory retina and a clinical course of between 12 and 60 months were treated. All eyes received large-spot TTT guided by indocyanine green angiography (ICGA). Subthreshold TTT was performed using an 810 nm diode laser with a spot size of 3.0 mm (power was set at 350 mW). Treatment was applied for 60 seconds to the areas of choroidal hyperfluorescence on ICGA.

Results: The mean number of TTT sessions was 1.4 ± 0.5. All eyes were followed up for at least 6 months (mean 9.6 ± 3.2 standard deviation; range 6-12 months). The mean logarithm of the minimum angle of resolution best-corrected visual acuity was significantly better compared with baseline. All TTT-treated eyes had stable or improved vision (P < 0.001). Mean optical coherence tomography (OCT) central foveal thickness was significantly lower in all patients (P < 0.001) compared with pretreatment OCT, with a reduction in subretinal fluid and resolution of serous detachment associated with anatomical fovea restoration. No patient had any treatment-related side effects.

Conclusion: Modified subthreshold TTT appears to have a beneficial effect in treating patients with CCSC and persistent neurosensory detachment. The encouraging results and lack of visually significant complications suggest that further investigation is warranted.

No MeSH data available.


Related in: MedlinePlus