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Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy.

Kitaguchi Y, Kusaka S, Yamaguchi T, Mihashi T, Fujikado T - Clin Ophthalmol (2011)

Bottom Line: The amplitudes of the mfERGs were decreased in the foveal area.The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan;

ABSTRACT

Purpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).

Design: Observational case reports.

Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.

Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.

Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

No MeSH data available.


Related in: MedlinePlus

Adaptive optics (AO) images of the fovea of a normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Bars represent 100 μm. In the eyes of the patients, signals from the cone mosaic were attenuated, and the bright spots were distorted (B–H). One eye which had normal visual acuity had an almost normal appearance in the foveal center, with some dark areas around the fovea.
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f3-opth-5-345: Adaptive optics (AO) images of the fovea of a normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Bars represent 100 μm. In the eyes of the patients, signals from the cone mosaic were attenuated, and the bright spots were distorted (B–H). One eye which had normal visual acuity had an almost normal appearance in the foveal center, with some dark areas around the fovea.

Mentions: The AO images showed patchy dark areas in all eyes, which disrupted the mosaic of bright spots in the fovea (Figures 3B–3H), compared with normal control (Figure 3A). This suggested a degeneration of some of the photoreceptors in this area. Nonuniform bright spots with irregular shapes and higher brightness appeared around the dark areas. In patient 3, the normal cone mosaic was replaced by dark areas, and nonuniform bright spots appeared to be all that remained (Figures 3F and 3G). In the left eye of patient 4, the mosaic of blight spots were in relatively good order with fewer dark areas in the center of the image (Figure 3I), although the mosaic was disrupted in the peripheral area.


Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy.

Kitaguchi Y, Kusaka S, Yamaguchi T, Mihashi T, Fujikado T - Clin Ophthalmol (2011)

Adaptive optics (AO) images of the fovea of a normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Bars represent 100 μm. In the eyes of the patients, signals from the cone mosaic were attenuated, and the bright spots were distorted (B–H). One eye which had normal visual acuity had an almost normal appearance in the foveal center, with some dark areas around the fovea.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3065578&req=5

f3-opth-5-345: Adaptive optics (AO) images of the fovea of a normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Bars represent 100 μm. In the eyes of the patients, signals from the cone mosaic were attenuated, and the bright spots were distorted (B–H). One eye which had normal visual acuity had an almost normal appearance in the foveal center, with some dark areas around the fovea.
Mentions: The AO images showed patchy dark areas in all eyes, which disrupted the mosaic of bright spots in the fovea (Figures 3B–3H), compared with normal control (Figure 3A). This suggested a degeneration of some of the photoreceptors in this area. Nonuniform bright spots with irregular shapes and higher brightness appeared around the dark areas. In patient 3, the normal cone mosaic was replaced by dark areas, and nonuniform bright spots appeared to be all that remained (Figures 3F and 3G). In the left eye of patient 4, the mosaic of blight spots were in relatively good order with fewer dark areas in the center of the image (Figure 3I), although the mosaic was disrupted in the peripheral area.

Bottom Line: The amplitudes of the mfERGs were decreased in the foveal area.The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan;

ABSTRACT

Purpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).

Design: Observational case reports.

Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.

Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.

Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

No MeSH data available.


Related in: MedlinePlus