Limits...
Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy.

Kitaguchi Y, Kusaka S, Yamaguchi T, Mihashi T, Fujikado T - Clin Ophthalmol (2011)

Bottom Line: The amplitudes of the mfERGs were decreased in the foveal area.The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan;

ABSTRACT

Purpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).

Design: Observational case reports.

Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.

Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.

Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

No MeSH data available.


Related in: MedlinePlus

Fourier-domain optical coherence tomography (FD-OCT) images (horizontal scan) of normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Horizontal bars represent 500 μm, and vertical bars represent 200 μm. The eyes in patients 1–4 had a bilateral symmetric decline in visual acuity, whereas those in patient 5 had an assymmetric decline (20/200 right eye, 20/20 left eye). FD-OCT in normal eye provided clear images of the retinal layers. The external limiting membrane (ELM), photoreceptors inner and outer segment (IS/OS) junction, third line, and retinal pigment epithelium (RPE) are distinguishable. Meanwhile, the retinal photoreceptor layer is not clear in the eyes of the patients. Although ELM was visualized in all eyes, IS/OS is elevated and disrupted in fovea (B, C, D, E, H), widely disrupted and not clear (F, G), and clearly visualized in one eye (I). The third line was visualized only in one eye (I), just in the fovea.
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f2-opth-5-345: Fourier-domain optical coherence tomography (FD-OCT) images (horizontal scan) of normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Horizontal bars represent 500 μm, and vertical bars represent 200 μm. The eyes in patients 1–4 had a bilateral symmetric decline in visual acuity, whereas those in patient 5 had an assymmetric decline (20/200 right eye, 20/20 left eye). FD-OCT in normal eye provided clear images of the retinal layers. The external limiting membrane (ELM), photoreceptors inner and outer segment (IS/OS) junction, third line, and retinal pigment epithelium (RPE) are distinguishable. Meanwhile, the retinal photoreceptor layer is not clear in the eyes of the patients. Although ELM was visualized in all eyes, IS/OS is elevated and disrupted in fovea (B, C, D, E, H), widely disrupted and not clear (F, G), and clearly visualized in one eye (I). The third line was visualized only in one eye (I), just in the fovea.

Mentions: All eyes showed a disruption of the IS/OS line except the left eye of patient 3 who had a visual acuity of 20/20; meanwhile the IS/OS line and the third line are easily identifiable in normal control. Both eyes of patients 1 and 2 had a severe disruption of IS/OS line in the center of the fovea, and both had a low-intensity space between the elevated external limiting membrane (ELM) and the retinal pigment epithelium (RPE) (Figures 2B–2E). In patient 3, the IS/OS line and the RPE line were disrupted, and the retina was thinner (Figures 2F and 2G). The outer segment layer between the IS/OS line and RPE line of the FD-OCT images was visible only in the center of the fovea in the left eye of patient 4 (Figure 2I).


Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy.

Kitaguchi Y, Kusaka S, Yamaguchi T, Mihashi T, Fujikado T - Clin Ophthalmol (2011)

Fourier-domain optical coherence tomography (FD-OCT) images (horizontal scan) of normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Horizontal bars represent 500 μm, and vertical bars represent 200 μm. The eyes in patients 1–4 had a bilateral symmetric decline in visual acuity, whereas those in patient 5 had an assymmetric decline (20/200 right eye, 20/20 left eye). FD-OCT in normal eye provided clear images of the retinal layers. The external limiting membrane (ELM), photoreceptors inner and outer segment (IS/OS) junction, third line, and retinal pigment epithelium (RPE) are distinguishable. Meanwhile, the retinal photoreceptor layer is not clear in the eyes of the patients. Although ELM was visualized in all eyes, IS/OS is elevated and disrupted in fovea (B, C, D, E, H), widely disrupted and not clear (F, G), and clearly visualized in one eye (I). The third line was visualized only in one eye (I), just in the fovea.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3065578&req=5

f2-opth-5-345: Fourier-domain optical coherence tomography (FD-OCT) images (horizontal scan) of normal eye (A), and right/left eyes of patient 1 (B, C), patient 2 (D, E), patient 3 (F, G), and patient 4 (H, I). Horizontal bars represent 500 μm, and vertical bars represent 200 μm. The eyes in patients 1–4 had a bilateral symmetric decline in visual acuity, whereas those in patient 5 had an assymmetric decline (20/200 right eye, 20/20 left eye). FD-OCT in normal eye provided clear images of the retinal layers. The external limiting membrane (ELM), photoreceptors inner and outer segment (IS/OS) junction, third line, and retinal pigment epithelium (RPE) are distinguishable. Meanwhile, the retinal photoreceptor layer is not clear in the eyes of the patients. Although ELM was visualized in all eyes, IS/OS is elevated and disrupted in fovea (B, C, D, E, H), widely disrupted and not clear (F, G), and clearly visualized in one eye (I). The third line was visualized only in one eye (I), just in the fovea.
Mentions: All eyes showed a disruption of the IS/OS line except the left eye of patient 3 who had a visual acuity of 20/20; meanwhile the IS/OS line and the third line are easily identifiable in normal control. Both eyes of patients 1 and 2 had a severe disruption of IS/OS line in the center of the fovea, and both had a low-intensity space between the elevated external limiting membrane (ELM) and the retinal pigment epithelium (RPE) (Figures 2B–2E). In patient 3, the IS/OS line and the RPE line were disrupted, and the retina was thinner (Figures 2F and 2G). The outer segment layer between the IS/OS line and RPE line of the FD-OCT images was visible only in the center of the fovea in the left eye of patient 4 (Figure 2I).

Bottom Line: The amplitudes of the mfERGs were decreased in the foveal area.The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan;

ABSTRACT

Purpose: To investigate the structural changes in the photoreceptors by adaptive optics (AO) fundus imaging and Fourier-domain optical coherence tomography (FD-OCT) in eyes with occult macular dystrophy (OMD).

Design: Observational case reports.

Methods: Eight eyes of four patients who were diagnosed with OMD were examined. All eyes had a complete ophthalmological examination. Multifocal electroretinograms (mfERGs) were recorded from all eyes. AO and FD-OCT images of foveal photoreceptors were obtained.

Results: The best-corrected visual acuity (BCVA) of these eyes ranged from 20/20 to 20/200, and the ocular fundus was normal by conventional ocular examination in all eyes. The amplitudes of the mfERGs were decreased in the foveal area. The inner and outer segment (IS/OS) junction of the photoreceptors in the foveal area was disrupted. The IS/OS junction was intact in one eye with a BCVA of 20/20, and the outer segment layer between the IS/OS junction and retinal pigment epithelium of the FD-OCT images was identified only in the center of the fovea. The AO images showed patchy dark areas in all eyes, which indicated a disruption of the mosaic of bright spots in the fovea.

Conclusion: Structural changes of photoreceptors in OMD patients were detected tangentially by FD-OCT and en face by AO.

No MeSH data available.


Related in: MedlinePlus