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Efficacy and tolerability of the fixed combination of brinzolamide 1% and timolol 0.5% in daily practice.

Lanzl I, Raber T - Clin Ophthalmol (2011)

Bottom Line: All of the predefined patient subgroups (grouped by previous therapy) demonstrated a significant mean IOP reduction following transition to brinzolamide/timolol (P < 0.0001).Patients who transitioned from dorzolamide/timolol to brinzolamide/timolol (n = 2937) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable than dorzolamide/timolol (88.9% vs 28.9%), and preferred brinzolamide/timolol at a ratio of more than 9:1.Patients who transitioned from brimonidine/timolol (n = 209) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable (86.5% vs 32.1%), and preferred brinzolamide/timolol at a ratio of 11.5:1.

View Article: PubMed Central - PubMed

Affiliation: Eye Department of the Technical University, Munich, Germany;

ABSTRACT

Introduction: The purpose of this study was to document the efficacy and tolerability of the new fixed-combination (FC) brinzolamide 1%/timolol 0.5% as used in daily practice throughout Germany.

Methods: An open-label, multicenter, observational study of patients was performed that evaluated the transition from prior medication to brinzolamide/timolol FC for the reduction of intraocular pressure (IOP). Ophthalmologists measured IOP at baseline and 4-6 weeks after transition and assessed their satisfaction with brinzolamide/timolol FC. Patients assessed the tolerability of both their previous and new regimens, judged their satisfaction with brinzolamide/timolol, and reported their preference between their previous and new regimens. Patients transitioning from other FC products to brinzolamide/timolol FC were analyzed separately.

Results: Data from 14,025 patients from 1161 centers were analyzed. Four to 6 weeks after transition to brinzolamide/timolol, patients experienced a mean IOP decrease of 3.9 ± 4.3 mm Hg (P < 0.0001). All of the predefined patient subgroups (grouped by previous therapy) demonstrated a significant mean IOP reduction following transition to brinzolamide/timolol (P < 0.0001). Patients judged brinzolamide/timolol tolerability more positively than they did their previous therapies (87.2% vs 53.7% favorable assessments) and reported a high satisfaction rating with brinzolamide/timolol (93.4%). Brinzolamide/timolol was preferred over previous therapy at a ratio of almost 9:1. Patients who transitioned from dorzolamide/timolol to brinzolamide/timolol (n = 2937) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable than dorzolamide/timolol (88.9% vs 28.9%), and preferred brinzolamide/timolol at a ratio of more than 9:1. Patients who transitioned from brimonidine/timolol (n = 209) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable (86.5% vs 32.1%), and preferred brinzolamide/timolol at a ratio of 11.5:1.

Conclusions: The FC brinzolamide 1%/timolol 0.5% produced better IOP control than all previous therapies analyzed and demonstrated favorable tolerability and a high satisfaction rating, resulting in a strong patient preference for brinzolamide/timolol over previous therapies.

No MeSH data available.


Related in: MedlinePlus

Patient-reported tolerability of brimonidine/timolol vs brinzolamide/timolol (n = 209).
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f5-opth-5-291: Patient-reported tolerability of brimonidine/timolol vs brinzolamide/timolol (n = 209).

Mentions: The most common previous therapy in this study was dorzolamide/timolol (N = 2937), representing over 20% of the total population. The majority of this subgroup of patients (56.7%) transitioned to brinzolamide/timolol because of intolerance to dorzolamide/timolol (as judged by the treating physician; Table 3), a proportion that was substantially higher than intolerance to previous therapy cited in the overall population (28.9%). When these patients were transitioned from dorzolamide/timolol to brinzolamide/timolol, mean IOP decreased by 10.8% from 18.5 ± 4.1 mm Hg to 16.5 ± 3.2 mm Hg (P < 0.0001). These patients rated the tolerability of brinzolamide/timolol substantially higher than they did dorzolamide/timolol, with the positive responses of very good and good increasing from 29.2% with dorzolamide/timolol to 88.9% with brinzolamide/timolol (Figure 3). Similar to the overall population, patients in this subgroup preferred brinzolamide/timolol over dorzolamide/timolol at a ratio of more than 9:1 (82.0% vs 8.8%; Figure 4). For the 209 patients who transitioned from FC brimonidine/timolol to brinzolamide/timolol, a reduction in mean IOP of 13.4% was observed (20.1 ± 4.0 mm Hg vs 17.4 ± 3.3 mm Hg; P < 0.0001). More patients rated brinzolamide/timolol favorably than they did brimonidine/timolol (86.5% vs 32.1%; Figure 5), and these patients preferred brinzolamide/timolol over brimonidine/timolol at a ratio of 11.5:1 (75.8% vs 6.6%; Figure 6).


Efficacy and tolerability of the fixed combination of brinzolamide 1% and timolol 0.5% in daily practice.

Lanzl I, Raber T - Clin Ophthalmol (2011)

Patient-reported tolerability of brimonidine/timolol vs brinzolamide/timolol (n = 209).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065570&req=5

f5-opth-5-291: Patient-reported tolerability of brimonidine/timolol vs brinzolamide/timolol (n = 209).
Mentions: The most common previous therapy in this study was dorzolamide/timolol (N = 2937), representing over 20% of the total population. The majority of this subgroup of patients (56.7%) transitioned to brinzolamide/timolol because of intolerance to dorzolamide/timolol (as judged by the treating physician; Table 3), a proportion that was substantially higher than intolerance to previous therapy cited in the overall population (28.9%). When these patients were transitioned from dorzolamide/timolol to brinzolamide/timolol, mean IOP decreased by 10.8% from 18.5 ± 4.1 mm Hg to 16.5 ± 3.2 mm Hg (P < 0.0001). These patients rated the tolerability of brinzolamide/timolol substantially higher than they did dorzolamide/timolol, with the positive responses of very good and good increasing from 29.2% with dorzolamide/timolol to 88.9% with brinzolamide/timolol (Figure 3). Similar to the overall population, patients in this subgroup preferred brinzolamide/timolol over dorzolamide/timolol at a ratio of more than 9:1 (82.0% vs 8.8%; Figure 4). For the 209 patients who transitioned from FC brimonidine/timolol to brinzolamide/timolol, a reduction in mean IOP of 13.4% was observed (20.1 ± 4.0 mm Hg vs 17.4 ± 3.3 mm Hg; P < 0.0001). More patients rated brinzolamide/timolol favorably than they did brimonidine/timolol (86.5% vs 32.1%; Figure 5), and these patients preferred brinzolamide/timolol over brimonidine/timolol at a ratio of 11.5:1 (75.8% vs 6.6%; Figure 6).

Bottom Line: All of the predefined patient subgroups (grouped by previous therapy) demonstrated a significant mean IOP reduction following transition to brinzolamide/timolol (P < 0.0001).Patients who transitioned from dorzolamide/timolol to brinzolamide/timolol (n = 2937) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable than dorzolamide/timolol (88.9% vs 28.9%), and preferred brinzolamide/timolol at a ratio of more than 9:1.Patients who transitioned from brimonidine/timolol (n = 209) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable (86.5% vs 32.1%), and preferred brinzolamide/timolol at a ratio of 11.5:1.

View Article: PubMed Central - PubMed

Affiliation: Eye Department of the Technical University, Munich, Germany;

ABSTRACT

Introduction: The purpose of this study was to document the efficacy and tolerability of the new fixed-combination (FC) brinzolamide 1%/timolol 0.5% as used in daily practice throughout Germany.

Methods: An open-label, multicenter, observational study of patients was performed that evaluated the transition from prior medication to brinzolamide/timolol FC for the reduction of intraocular pressure (IOP). Ophthalmologists measured IOP at baseline and 4-6 weeks after transition and assessed their satisfaction with brinzolamide/timolol FC. Patients assessed the tolerability of both their previous and new regimens, judged their satisfaction with brinzolamide/timolol, and reported their preference between their previous and new regimens. Patients transitioning from other FC products to brinzolamide/timolol FC were analyzed separately.

Results: Data from 14,025 patients from 1161 centers were analyzed. Four to 6 weeks after transition to brinzolamide/timolol, patients experienced a mean IOP decrease of 3.9 ± 4.3 mm Hg (P < 0.0001). All of the predefined patient subgroups (grouped by previous therapy) demonstrated a significant mean IOP reduction following transition to brinzolamide/timolol (P < 0.0001). Patients judged brinzolamide/timolol tolerability more positively than they did their previous therapies (87.2% vs 53.7% favorable assessments) and reported a high satisfaction rating with brinzolamide/timolol (93.4%). Brinzolamide/timolol was preferred over previous therapy at a ratio of almost 9:1. Patients who transitioned from dorzolamide/timolol to brinzolamide/timolol (n = 2937) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable than dorzolamide/timolol (88.9% vs 28.9%), and preferred brinzolamide/timolol at a ratio of more than 9:1. Patients who transitioned from brimonidine/timolol (n = 209) demonstrated a significant decrease in mean IOP (P < 0.0001), rated brinzolamide/timolol more tolerable (86.5% vs 32.1%), and preferred brinzolamide/timolol at a ratio of 11.5:1.

Conclusions: The FC brinzolamide 1%/timolol 0.5% produced better IOP control than all previous therapies analyzed and demonstrated favorable tolerability and a high satisfaction rating, resulting in a strong patient preference for brinzolamide/timolol over previous therapies.

No MeSH data available.


Related in: MedlinePlus