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Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets.

Turan S, Topcu B, Gökçe İ, Güran T, Atay Z, Omar A, Akçay T, Bereket A - J Clin Res Pediatr Endocrinol (2011)

Bottom Line: Additionally, different buffers used even in the same method cause variable results.Similarly, plasma parathormone(PTH) levels ranged from highest to lowest in the VDDR, NR and HR groups (median values: 525, 237 and 98 pg/mL, respectively; p<0.001).This normative data will provide a basis for better evaluation of ALP levels determined by the described method.

View Article: PubMed Central - PubMed

Affiliation: Marmara University, Department of Pediatric Endocrinology, İstanbul, Turkey. serap.turan@marmara.edu.tr

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Related in: MedlinePlus

ALP levels in different types of rickets, full circles representing NR, stars VDDR and empty circles HR ALP: alkaline phosphatase, NR: nutritional rickets, VDDR: vitamin-D dependent ricket, HR: hypophosphatemic rickets
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fg4: ALP levels in different types of rickets, full circles representing NR, stars VDDR and empty circles HR ALP: alkaline phosphatase, NR: nutritional rickets, VDDR: vitamin-D dependent ricket, HR: hypophosphatemic rickets

Mentions: performed in the groups of VDDR and HR before treatment as well as after the start of treatment if they continued to have signs of active rickets related to compliance or other problems at follow-up. A total of 39 samples from 38 cases with NR, 19 samples from 7 cases with VDDR, and 20 samples from 8 cases with HR were obtained for final analysis. The biochemical data of patients with rickets are presented in Table 2. Serum ALP levels were highest in the VDDR group and lowest in the HR group. ALP z-score was significantly lower in the HR group (median: 3.6) than in the VDDR (median: 10.4) and NR (median: 6.5) groups (p<0.001). A similar pattern was observed for plasma PTH levels from highest to lowest in VDDR, NR and HR (median values of 525, 237 and 98 pg/mL, respectively). There were statistically significant differences among the three groups (p<0.001). Serum calcium levels were highest and serum phosphate levels were lowest in the HR group (HR vs. VDDR and NR; medians: 9.4 vs. 8.9 and 8.8 mg/dL for Ca, 2.5 vs. 2.9 and 2.9 mg/dL for phosphate, respectively; p<0.05). Serum ALP levels of the individual patients are shown in Figure 2.


Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets.

Turan S, Topcu B, Gökçe İ, Güran T, Atay Z, Omar A, Akçay T, Bereket A - J Clin Res Pediatr Endocrinol (2011)

ALP levels in different types of rickets, full circles representing NR, stars VDDR and empty circles HR ALP: alkaline phosphatase, NR: nutritional rickets, VDDR: vitamin-D dependent ricket, HR: hypophosphatemic rickets
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3065317&req=5

fg4: ALP levels in different types of rickets, full circles representing NR, stars VDDR and empty circles HR ALP: alkaline phosphatase, NR: nutritional rickets, VDDR: vitamin-D dependent ricket, HR: hypophosphatemic rickets
Mentions: performed in the groups of VDDR and HR before treatment as well as after the start of treatment if they continued to have signs of active rickets related to compliance or other problems at follow-up. A total of 39 samples from 38 cases with NR, 19 samples from 7 cases with VDDR, and 20 samples from 8 cases with HR were obtained for final analysis. The biochemical data of patients with rickets are presented in Table 2. Serum ALP levels were highest in the VDDR group and lowest in the HR group. ALP z-score was significantly lower in the HR group (median: 3.6) than in the VDDR (median: 10.4) and NR (median: 6.5) groups (p<0.001). A similar pattern was observed for plasma PTH levels from highest to lowest in VDDR, NR and HR (median values of 525, 237 and 98 pg/mL, respectively). There were statistically significant differences among the three groups (p<0.001). Serum calcium levels were highest and serum phosphate levels were lowest in the HR group (HR vs. VDDR and NR; medians: 9.4 vs. 8.9 and 8.8 mg/dL for Ca, 2.5 vs. 2.9 and 2.9 mg/dL for phosphate, respectively; p<0.05). Serum ALP levels of the individual patients are shown in Figure 2.

Bottom Line: Additionally, different buffers used even in the same method cause variable results.Similarly, plasma parathormone(PTH) levels ranged from highest to lowest in the VDDR, NR and HR groups (median values: 525, 237 and 98 pg/mL, respectively; p<0.001).This normative data will provide a basis for better evaluation of ALP levels determined by the described method.

View Article: PubMed Central - PubMed

Affiliation: Marmara University, Department of Pediatric Endocrinology, İstanbul, Turkey. serap.turan@marmara.edu.tr

Show MeSH
Related in: MedlinePlus