Serum alkaline phosphatase levels in healthy children and evaluation of alkaline phosphatase z-scores in different types of rickets.
Bottom Line: ALP levels start to decline after age 12 and 14 in girls and boys, respectively.Serum ALP levels were highest in the VDDR group and lowest in the HR group (median z-score values in HR, VDDR and NR were 3.6, 10.4 and 6.5, respectively; p<0.001).Similarly, plasma parathormone(PTH) levels ranged from highest to lowest in the VDDR, NR and HR groups (median values: 525, 237 and 98 pg/mL, respectively; p<0.001).
Affiliation: Marmara University, Department of Pediatric Endocrinology, İstanbul, Turkey. email@example.comShow MeSH
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Mentions: performed in the groups of VDDR and HR before treatment as well as after the start of treatment if they continued to have signs of active rickets related to compliance or other problems at follow-up. A total of 39 samples from 38 cases with NR, 19 samples from 7 cases with VDDR, and 20 samples from 8 cases with HR were obtained for final analysis. The biochemical data of patients with rickets are presented in Table 2. Serum ALP levels were highest in the VDDR group and lowest in the HR group. ALP z-score was significantly lower in the HR group (median: 3.6) than in the VDDR (median: 10.4) and NR (median: 6.5) groups (p<0.001). A similar pattern was observed for plasma PTH levels from highest to lowest in VDDR, NR and HR (median values of 525, 237 and 98 pg/mL, respectively). There were statistically significant differences among the three groups (p<0.001). Serum calcium levels were highest and serum phosphate levels were lowest in the HR group (HR vs. VDDR and NR; medians: 9.4 vs. 8.9 and 8.8 mg/dL for Ca, 2.5 vs. 2.9 and 2.9 mg/dL for phosphate, respectively; p<0.05). Serum ALP levels of the individual patients are shown in Figure 2.
Affiliation: Marmara University, Department of Pediatric Endocrinology, İstanbul, Turkey. firstname.lastname@example.org