GnRH stimulation test in precocious puberty: single sample is adequate for diagnosis and dose adjustment.
Bottom Line: However, the test is costly, time-consuming and uncomfortable.Forty-minute post-injection samples had the greatest frequency of "peaking luteinizing hormone (LH)" (p<0.001) in the diagnostic tests when the cut-off value was taken as 5 IU/L for LH, 40th minute sample was found to have 98% sensitivity and 100% specificity in the diagnosis of precocious puberty, while the sensitivity and specificity of the 20th minute sample was 100% in the assessment of pubertal suppression.LH level at the 40th minute post-injection in the diagnosis of central precocious puberty and at the 20th minute post-injection in the assessment of pubertal suppression is highly sensitive and specific.
Affiliation: Pediatric Endocrinology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.Show MeSH
Related in: MedlinePlus
Mentions: Evaluation of LH/FSH ratio demonstrated no statistically significant difference in LH/FSH ratios between prepubertal and pubertal response groups both in the basal state (p=0.328) and in the peaks (p=0.718). Sensitivity and specificity of basal and peak LH levels are shown in Figure 3.
Affiliation: Pediatric Endocrinology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.