Massive genomic rearrangement acquired in a single catastrophic event during cancer development.
Bottom Line: Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states.The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ∼25% of bone cancers.We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis.
Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.Show MeSH
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Mentions: We selected four of these cell lines for further genomic analysis with massively parallel paired-end sequencing for rearrangements and cytogenetic studies: SNU-C1, 8505C, TK10, and SCLC-21H (described later). In SNU-C1, derived from a colorectal cancer, we identified 239 rearrangements involving chromosome 15 (Figure 2A and Table S2). From 8505C, a thyroid cancer line, we mapped 77 rearrangements involving the short arm of chromosome 9 (Figure 2B and Table S2), and for TK10, a renal cancer, 55 rearrangements involving chromosome 5 (Figure 2C and Table S2).
Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.