Massive genomic rearrangement acquired in a single catastrophic event during cancer development.
Bottom Line: Rearrangements involving one or a few chromosomes crisscross back and forth across involved regions, generating frequent oscillations between two copy number states.The stamp of chromothripsis can be seen in at least 2%-3% of all cancers, across many subtypes, and is present in ∼25% of bone cancers.We find that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis.
Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.Show MeSH
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Affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.