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Anticancer drugs from marine flora: an overview.

Sithranga Boopathy N, Kathiresan K - J Oncol (2011)

Bottom Line: The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides.The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumour activities.In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds.

View Article: PubMed Central - PubMed

Affiliation: Center of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.

ABSTRACT
Marine floras, such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds, mangroves, and other halophytes are extremely important oceanic resources, constituting over 90% of the oceanic biomass. They are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides. The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumour activities. The phytochemicals possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis. In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds. Hence, this paper reviews the works so far conducted on this aspect with a view to provide a baseline information for promoting the marine flora-based anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease.

No MeSH data available.


Related in: MedlinePlus

Anticancer polyphenolic compounds from marine floras.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3065217&req=5

fig1: Anticancer polyphenolic compounds from marine floras.

Mentions: The marine red algae like Osmundea pinnatifida has been documented for its antimicrobial, antifungal, anti-leishmanial, and antioxidant [111–114] activities. Scutellarein 4′-methyl ether (Figure 1(a)) has antiallergic [115], anticancer and anticytotoxic activities in vitro and in vivo [116].


Anticancer drugs from marine flora: an overview.

Sithranga Boopathy N, Kathiresan K - J Oncol (2011)

Anticancer polyphenolic compounds from marine floras.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065217&req=5

fig1: Anticancer polyphenolic compounds from marine floras.
Mentions: The marine red algae like Osmundea pinnatifida has been documented for its antimicrobial, antifungal, anti-leishmanial, and antioxidant [111–114] activities. Scutellarein 4′-methyl ether (Figure 1(a)) has antiallergic [115], anticancer and anticytotoxic activities in vitro and in vivo [116].

Bottom Line: The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides.The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumour activities.In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds.

View Article: PubMed Central - PubMed

Affiliation: Center of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.

ABSTRACT
Marine floras, such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds, mangroves, and other halophytes are extremely important oceanic resources, constituting over 90% of the oceanic biomass. They are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides. The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumour activities. The phytochemicals possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis. In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds. Hence, this paper reviews the works so far conducted on this aspect with a view to provide a baseline information for promoting the marine flora-based anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease.

No MeSH data available.


Related in: MedlinePlus