Limits...
Value and Safety of Midazolam Anesthesia during Transrectal Ultrasound-Guided Prostate Biopsy.

Song JH, Doo SW, Yang WJ, Song YS, Kim GW, Ku JH, Lee CH - Korean J Urol (2011)

Bottom Line: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05).Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy.Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Although transrectal ultrasound-guided prostate biopsy is useful for diagnosing prostate cancer, it is a painful procedure. There are many methods for providing pain relief and for treating discomfort during the procedure, but occasionally these are reported to be of limited use. We aimed to evaluate the value and safety of midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy.

Materials and methods: From August 2008 to December 2009, 104 male patients, who were examined with transrectal ultrasound-guided prostate 12-core biopsy, were randomly assigned to two groups. Group 1 (n=51) received ketorolac (Tarasyn®) 30 mg. Group 2 (n=53) was treated with midazolam (Dormicum®) 3 mg, which was increased to 5 mg if necessary. Immediately after the procedure, the patients were asked to rate their comfort level by using a 10-point visual analog self-assessment pain scale.

Results: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05). The patients assigned to group 2 experienced no side-effects from midazolam and were more satisfied than the patients in group 1 (p<0.05).

Conclusions: Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy. Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

No MeSH data available.


Related in: MedlinePlus

Distribution of the cases in regard to the degree of cognition Mini-Mental State Examination (MMSE).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC3065136&req=5

Figure 4: Distribution of the cases in regard to the degree of cognition Mini-Mental State Examination (MMSE).

Mentions: Overall, 40 patients had a baseline MMSE score of ≥25 (normal), 13 had an MMSE score of 21-24 (mild), and no patients had an MMSE score of ≤20 (moderate to severe). After prostate biopsy, an MMSE score of ≥25 was found in 39 patients, an MMSE score of 21-24 was found in 14 patients, and an MMSE score of ≤20 was not found (Fig. 4). The difference in the MMSE score was not significant after the midazolam anesthesia and there was no cognitive change to moderate or severe (score below 20). Side effects of midazolam administration have been seen in some patients [28,29]. However, no patients in this study had to be treated for side effects after midazolam anesthesia. Our study indicates that midazolam anesthesia during prostate biopsy is well tolerated and is associated with no or minimal discomfort.


Value and Safety of Midazolam Anesthesia during Transrectal Ultrasound-Guided Prostate Biopsy.

Song JH, Doo SW, Yang WJ, Song YS, Kim GW, Ku JH, Lee CH - Korean J Urol (2011)

Distribution of the cases in regard to the degree of cognition Mini-Mental State Examination (MMSE).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3065136&req=5

Figure 4: Distribution of the cases in regard to the degree of cognition Mini-Mental State Examination (MMSE).
Mentions: Overall, 40 patients had a baseline MMSE score of ≥25 (normal), 13 had an MMSE score of 21-24 (mild), and no patients had an MMSE score of ≤20 (moderate to severe). After prostate biopsy, an MMSE score of ≥25 was found in 39 patients, an MMSE score of 21-24 was found in 14 patients, and an MMSE score of ≤20 was not found (Fig. 4). The difference in the MMSE score was not significant after the midazolam anesthesia and there was no cognitive change to moderate or severe (score below 20). Side effects of midazolam administration have been seen in some patients [28,29]. However, no patients in this study had to be treated for side effects after midazolam anesthesia. Our study indicates that midazolam anesthesia during prostate biopsy is well tolerated and is associated with no or minimal discomfort.

Bottom Line: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05).Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy.Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Although transrectal ultrasound-guided prostate biopsy is useful for diagnosing prostate cancer, it is a painful procedure. There are many methods for providing pain relief and for treating discomfort during the procedure, but occasionally these are reported to be of limited use. We aimed to evaluate the value and safety of midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy.

Materials and methods: From August 2008 to December 2009, 104 male patients, who were examined with transrectal ultrasound-guided prostate 12-core biopsy, were randomly assigned to two groups. Group 1 (n=51) received ketorolac (Tarasyn®) 30 mg. Group 2 (n=53) was treated with midazolam (Dormicum®) 3 mg, which was increased to 5 mg if necessary. Immediately after the procedure, the patients were asked to rate their comfort level by using a 10-point visual analog self-assessment pain scale.

Results: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05). The patients assigned to group 2 experienced no side-effects from midazolam and were more satisfied than the patients in group 1 (p<0.05).

Conclusions: Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy. Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

No MeSH data available.


Related in: MedlinePlus