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Value and Safety of Midazolam Anesthesia during Transrectal Ultrasound-Guided Prostate Biopsy.

Song JH, Doo SW, Yang WJ, Song YS, Kim GW, Ku JH, Lee CH - Korean J Urol (2011)

Bottom Line: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05).Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy.Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Although transrectal ultrasound-guided prostate biopsy is useful for diagnosing prostate cancer, it is a painful procedure. There are many methods for providing pain relief and for treating discomfort during the procedure, but occasionally these are reported to be of limited use. We aimed to evaluate the value and safety of midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy.

Materials and methods: From August 2008 to December 2009, 104 male patients, who were examined with transrectal ultrasound-guided prostate 12-core biopsy, were randomly assigned to two groups. Group 1 (n=51) received ketorolac (Tarasyn®) 30 mg. Group 2 (n=53) was treated with midazolam (Dormicum®) 3 mg, which was increased to 5 mg if necessary. Immediately after the procedure, the patients were asked to rate their comfort level by using a 10-point visual analog self-assessment pain scale.

Results: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05). The patients assigned to group 2 experienced no side-effects from midazolam and were more satisfied than the patients in group 1 (p<0.05).

Conclusions: Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy. Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

No MeSH data available.


Related in: MedlinePlus

Comparision of the groups for mean pain scale and satisfaction percentil.
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Figure 3: Comparision of the groups for mean pain scale and satisfaction percentil.

Mentions: There were no significant differences in age, weight, body mass index, PSA, or prostate volume among the groups (Table 3). The differences in the pain scores were statistically significant (p<0.05). In group 1, none or mild degrees of discomfort were expressed by 7 (13.7%) cases and severe or intolerable discomfort by 19 (37.2%), respectively. In group 2, none or mild degrees of discomfort were reported by 31 (58.5%) cases, whereas severe or intolerable discomfort occurred in only 1 (1.8%) patient (Fig. 2). In group 1, satisfaction with the pain control methods was noted in 11 (21.5%) cases and willingness to undergo a repeat biopsy by using the same pain control measures was noted in 10 (19.6%) cases. Satisfaction and willingness were higher in group 2 than in group 1 (75.5% and 60.3%, respectively, p<0.05) (Fig. 3).


Value and Safety of Midazolam Anesthesia during Transrectal Ultrasound-Guided Prostate Biopsy.

Song JH, Doo SW, Yang WJ, Song YS, Kim GW, Ku JH, Lee CH - Korean J Urol (2011)

Comparision of the groups for mean pain scale and satisfaction percentil.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3065136&req=5

Figure 3: Comparision of the groups for mean pain scale and satisfaction percentil.
Mentions: There were no significant differences in age, weight, body mass index, PSA, or prostate volume among the groups (Table 3). The differences in the pain scores were statistically significant (p<0.05). In group 1, none or mild degrees of discomfort were expressed by 7 (13.7%) cases and severe or intolerable discomfort by 19 (37.2%), respectively. In group 2, none or mild degrees of discomfort were reported by 31 (58.5%) cases, whereas severe or intolerable discomfort occurred in only 1 (1.8%) patient (Fig. 2). In group 1, satisfaction with the pain control methods was noted in 11 (21.5%) cases and willingness to undergo a repeat biopsy by using the same pain control measures was noted in 10 (19.6%) cases. Satisfaction and willingness were higher in group 2 than in group 1 (75.5% and 60.3%, respectively, p<0.05) (Fig. 3).

Bottom Line: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05).Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy.Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Although transrectal ultrasound-guided prostate biopsy is useful for diagnosing prostate cancer, it is a painful procedure. There are many methods for providing pain relief and for treating discomfort during the procedure, but occasionally these are reported to be of limited use. We aimed to evaluate the value and safety of midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy.

Materials and methods: From August 2008 to December 2009, 104 male patients, who were examined with transrectal ultrasound-guided prostate 12-core biopsy, were randomly assigned to two groups. Group 1 (n=51) received ketorolac (Tarasyn®) 30 mg. Group 2 (n=53) was treated with midazolam (Dormicum®) 3 mg, which was increased to 5 mg if necessary. Immediately after the procedure, the patients were asked to rate their comfort level by using a 10-point visual analog self-assessment pain scale.

Results: The pain scale in group 2 was significantly lower than that in group 1 (p<0.05). The patients assigned to group 2 experienced no side-effects from midazolam and were more satisfied than the patients in group 1 (p<0.05).

Conclusions: Midazolam anesthesia relieves pain effectively, and the patient's satisfaction is better than with conventional transrectal ultrasound-guided prostate biopsy. Midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy is useful and safe.

No MeSH data available.


Related in: MedlinePlus