Limits...
Anterior mediastinal mass: a rare presentation of tuberculosis.

Khilnani GC, Jain N, Hadda V, Arava SK - J Trop Med (2011)

Bottom Line: Along with this, the patient also reported a reduction in his appetite and body weight.The histopathology revealed multiple epithelioid cell granulomas with necrosis, and the diagnosis of tuberculosis was made.The clinical course of this patient and the relevant literature is presented in this paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 028, India.

ABSTRACT
We report a case of a 14-year-boy who presented to us with a low-grade fever with evening rise for 9 months. Along with this, the patient also reported a reduction in his appetite and body weight. He had a mild dry cough but no respiratory symptoms otherwise. There was no other localization for fever on history. He received antitubercular therapy, based on abnormal chest radiograph. However, there was no relief in his symptoms. General physical examination revealed mild fever. Systemic examination was unremarkable. Blood investigations done for fever were noncontributory. Computed tomographic (CT) scan of the chest revealed a mediastinal mass compressing the trachea. The possibilities of lymphoma or germ cell tumour were considered. A biopsy from the mass under CT guidance was performed. The histopathology revealed multiple epithelioid cell granulomas with necrosis, and the diagnosis of tuberculosis was made. The clinical course of this patient and the relevant literature is presented in this paper.

No MeSH data available.


Related in: MedlinePlus

© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3065044&req=5

Mentions: Based on the presence of necrotizing granulomas, a diagnosis of tuberculosis was entertained. Considering the possibility of drug resistance, based on the past history of treatment with antituberculosis drugs twice, a 6-drug ATT regimen that included rifampicin (450 mg), isoniazid (300 mg), ethambutol (800 mg), pyrazinamide (1250 mg), streptomycin (0.75 gm), and levofloxacin (750 mg) along with pyridoxine was started. He showed improvement in symptoms after two months and radiological improvement on chest radiograph done after three months. A follow-up CECT scan of the chest done after 9 months of ATT showed almost complete resolution of the mass (Figure 3). The ATT was reduced to two drugs including isoniazid with pyridoxine and rifampicin with an intention to give it for 3 more months.


Anterior mediastinal mass: a rare presentation of tuberculosis.

Khilnani GC, Jain N, Hadda V, Arava SK - J Trop Med (2011)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065044&req=5

Mentions: Based on the presence of necrotizing granulomas, a diagnosis of tuberculosis was entertained. Considering the possibility of drug resistance, based on the past history of treatment with antituberculosis drugs twice, a 6-drug ATT regimen that included rifampicin (450 mg), isoniazid (300 mg), ethambutol (800 mg), pyrazinamide (1250 mg), streptomycin (0.75 gm), and levofloxacin (750 mg) along with pyridoxine was started. He showed improvement in symptoms after two months and radiological improvement on chest radiograph done after three months. A follow-up CECT scan of the chest done after 9 months of ATT showed almost complete resolution of the mass (Figure 3). The ATT was reduced to two drugs including isoniazid with pyridoxine and rifampicin with an intention to give it for 3 more months.

Bottom Line: Along with this, the patient also reported a reduction in his appetite and body weight.The histopathology revealed multiple epithelioid cell granulomas with necrosis, and the diagnosis of tuberculosis was made.The clinical course of this patient and the relevant literature is presented in this paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 028, India.

ABSTRACT
We report a case of a 14-year-boy who presented to us with a low-grade fever with evening rise for 9 months. Along with this, the patient also reported a reduction in his appetite and body weight. He had a mild dry cough but no respiratory symptoms otherwise. There was no other localization for fever on history. He received antitubercular therapy, based on abnormal chest radiograph. However, there was no relief in his symptoms. General physical examination revealed mild fever. Systemic examination was unremarkable. Blood investigations done for fever were noncontributory. Computed tomographic (CT) scan of the chest revealed a mediastinal mass compressing the trachea. The possibilities of lymphoma or germ cell tumour were considered. A biopsy from the mass under CT guidance was performed. The histopathology revealed multiple epithelioid cell granulomas with necrosis, and the diagnosis of tuberculosis was made. The clinical course of this patient and the relevant literature is presented in this paper.

No MeSH data available.


Related in: MedlinePlus