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Quantitative model for efficient temporal targeting of tumor cells and neovasculature.

Kohandel M, Haselwandter CA, Kardar M, Sengupta S, Sivaloganathan S - Comput Math Methods Med (2011)

Bottom Line: However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome.Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue.The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Mathematics, University of Waterloo, Waterloo, ON, Canada. kohandel@math.uwaterloo.ca

ABSTRACT
The combination of cytotoxic therapies and antiangiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.

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Related in: MedlinePlus

The tumor volume obtained with a 5% increase in (a)  and (b)  for Lewis lung carcinoma.
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fig5: The tumor volume obtained with a 5% increase in (a) and (b) for Lewis lung carcinoma.

Mentions: To investigate whether the trends obtained from our model for different treatments are robust with respect to changes in the model parameters, we performed numerical simulations of our model using parameterizations for which or were increased by 5% while all other model parameters were held fixed. As shown in Figure 5, these variations do not affect the trends illustrated in Figure 2(a).


Quantitative model for efficient temporal targeting of tumor cells and neovasculature.

Kohandel M, Haselwandter CA, Kardar M, Sengupta S, Sivaloganathan S - Comput Math Methods Med (2011)

The tumor volume obtained with a 5% increase in (a)  and (b)  for Lewis lung carcinoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065043&req=5

fig5: The tumor volume obtained with a 5% increase in (a) and (b) for Lewis lung carcinoma.
Mentions: To investigate whether the trends obtained from our model for different treatments are robust with respect to changes in the model parameters, we performed numerical simulations of our model using parameterizations for which or were increased by 5% while all other model parameters were held fixed. As shown in Figure 5, these variations do not affect the trends illustrated in Figure 2(a).

Bottom Line: However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome.Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue.The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Mathematics, University of Waterloo, Waterloo, ON, Canada. kohandel@math.uwaterloo.ca

ABSTRACT
The combination of cytotoxic therapies and antiangiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.

Show MeSH
Related in: MedlinePlus