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Resting-state glucose metabolism level is associated with the regional pattern of amyloid pathology in Alzheimer's disease.

Shin J, Tsui W, Li Y, Lee SY, Kim SJ, Cho SJ, Kim YB, de Leon MJ - Int J Alzheimers Dis (2011)

Bottom Line: We confirmed that resting glucose metabolism within the posterior components of the brain's default network is high in normal elderly subjects and low in AD patients, which is partially in agreement with the regional pattern of PIB uptake within the default network of AD patients.However, in several regions outside the default network, glucose metabolism was high in normal elderly subjects but was not depressed in AD patients, who exhibited significantly increased PIB uptakes in these regions.In contrast, the level of resting glucose metabolism in the default network and in regions outside the default network in normal elderly subjects was significantly correlated with the level of regional PIB uptake in AD patients.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Research Institute and Department of Psychiatry, Gachon University of Medicine and Science, Incheon 405-760, Republic of Korea.

ABSTRACT
It has been suggested that glucose metabolism within the brain's default network is directly associated with-and may even cause-the amyloid pathology of Alzheimer's disease (AD). Here we performed 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) and [(11)C]-labeled Pittsburgh Compound B (PIB) positron emission tomography (PET) on cognitively normal elderly subjects and on AD patients and conducted quantitative regional analysis of FDG- and PIB-PET images using an automated region of interest technique. We confirmed that resting glucose metabolism within the posterior components of the brain's default network is high in normal elderly subjects and low in AD patients, which is partially in agreement with the regional pattern of PIB uptake within the default network of AD patients. However, in several regions outside the default network, glucose metabolism was high in normal elderly subjects but was not depressed in AD patients, who exhibited significantly increased PIB uptakes in these regions. In contrast, the level of resting glucose metabolism in the default network and in regions outside the default network in normal elderly subjects was significantly correlated with the level of regional PIB uptake in AD patients. These results are discussed with experimental evidence suggesting that beta amyloid production and amyloid precursor protein regulation are dependent on neuronal activity.

No MeSH data available.


Related in: MedlinePlus

Regional PIB uptakes in normal control subjects and Alzheimer's disease (AD) patients. Mean and SE of SUVRs for PIB-PET in various brain regions in normal (black bars) and AD subjects (gray bars). MFG: middle frontal gyrus, MTC: medial temporal cortex, LTC: lateral temporal cortex, IP: inferior parietal lobe, PCC: posterior cingulate cortex, PFC: prefrontal cortex, OFC: orbitofrontal cortex, HIP: hippocampus, PU: putamen, STG: superior temporal gyrus, TH: thalamus, VC: visual cortex, OC: occipital cortex, AMY: amygdala. *P < .05, two-tailed t test.
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fig3: Regional PIB uptakes in normal control subjects and Alzheimer's disease (AD) patients. Mean and SE of SUVRs for PIB-PET in various brain regions in normal (black bars) and AD subjects (gray bars). MFG: middle frontal gyrus, MTC: medial temporal cortex, LTC: lateral temporal cortex, IP: inferior parietal lobe, PCC: posterior cingulate cortex, PFC: prefrontal cortex, OFC: orbitofrontal cortex, HIP: hippocampus, PU: putamen, STG: superior temporal gyrus, TH: thalamus, VC: visual cortex, OC: occipital cortex, AMY: amygdala. *P < .05, two-tailed t test.

Mentions: Figure 3 shows the mean and SE of SUVRs for PIB-PET for the default and nondefault networks of normal elderly subjects and AD patients. In AD patients, the regions of the brain can be classed into two groups based on PIB uptake: regions with high PIB uptake (the MFG, LTC, IP, PCC, PFC, and OFC in the default network and the PU, STG, TH, VC, and OC in the nondefault network) and regions with low PIB uptake (the MTC and HIP in the default network and the AMY in the nondefault network).


Resting-state glucose metabolism level is associated with the regional pattern of amyloid pathology in Alzheimer's disease.

Shin J, Tsui W, Li Y, Lee SY, Kim SJ, Cho SJ, Kim YB, de Leon MJ - Int J Alzheimers Dis (2011)

Regional PIB uptakes in normal control subjects and Alzheimer's disease (AD) patients. Mean and SE of SUVRs for PIB-PET in various brain regions in normal (black bars) and AD subjects (gray bars). MFG: middle frontal gyrus, MTC: medial temporal cortex, LTC: lateral temporal cortex, IP: inferior parietal lobe, PCC: posterior cingulate cortex, PFC: prefrontal cortex, OFC: orbitofrontal cortex, HIP: hippocampus, PU: putamen, STG: superior temporal gyrus, TH: thalamus, VC: visual cortex, OC: occipital cortex, AMY: amygdala. *P < .05, two-tailed t test.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065040&req=5

fig3: Regional PIB uptakes in normal control subjects and Alzheimer's disease (AD) patients. Mean and SE of SUVRs for PIB-PET in various brain regions in normal (black bars) and AD subjects (gray bars). MFG: middle frontal gyrus, MTC: medial temporal cortex, LTC: lateral temporal cortex, IP: inferior parietal lobe, PCC: posterior cingulate cortex, PFC: prefrontal cortex, OFC: orbitofrontal cortex, HIP: hippocampus, PU: putamen, STG: superior temporal gyrus, TH: thalamus, VC: visual cortex, OC: occipital cortex, AMY: amygdala. *P < .05, two-tailed t test.
Mentions: Figure 3 shows the mean and SE of SUVRs for PIB-PET for the default and nondefault networks of normal elderly subjects and AD patients. In AD patients, the regions of the brain can be classed into two groups based on PIB uptake: regions with high PIB uptake (the MFG, LTC, IP, PCC, PFC, and OFC in the default network and the PU, STG, TH, VC, and OC in the nondefault network) and regions with low PIB uptake (the MTC and HIP in the default network and the AMY in the nondefault network).

Bottom Line: We confirmed that resting glucose metabolism within the posterior components of the brain's default network is high in normal elderly subjects and low in AD patients, which is partially in agreement with the regional pattern of PIB uptake within the default network of AD patients.However, in several regions outside the default network, glucose metabolism was high in normal elderly subjects but was not depressed in AD patients, who exhibited significantly increased PIB uptakes in these regions.In contrast, the level of resting glucose metabolism in the default network and in regions outside the default network in normal elderly subjects was significantly correlated with the level of regional PIB uptake in AD patients.

View Article: PubMed Central - PubMed

Affiliation: Neuroscience Research Institute and Department of Psychiatry, Gachon University of Medicine and Science, Incheon 405-760, Republic of Korea.

ABSTRACT
It has been suggested that glucose metabolism within the brain's default network is directly associated with-and may even cause-the amyloid pathology of Alzheimer's disease (AD). Here we performed 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) and [(11)C]-labeled Pittsburgh Compound B (PIB) positron emission tomography (PET) on cognitively normal elderly subjects and on AD patients and conducted quantitative regional analysis of FDG- and PIB-PET images using an automated region of interest technique. We confirmed that resting glucose metabolism within the posterior components of the brain's default network is high in normal elderly subjects and low in AD patients, which is partially in agreement with the regional pattern of PIB uptake within the default network of AD patients. However, in several regions outside the default network, glucose metabolism was high in normal elderly subjects but was not depressed in AD patients, who exhibited significantly increased PIB uptakes in these regions. In contrast, the level of resting glucose metabolism in the default network and in regions outside the default network in normal elderly subjects was significantly correlated with the level of regional PIB uptake in AD patients. These results are discussed with experimental evidence suggesting that beta amyloid production and amyloid precursor protein regulation are dependent on neuronal activity.

No MeSH data available.


Related in: MedlinePlus