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Morphological changes of parotid gland in experimental hyperlipidemia.

Daskala ID, Tesseromatis CC - Int J Dent (2011)

Bottom Line: Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased.Conclusions.The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Dentistry, University of Athens, 11527 Goudi, Greece.

ABSTRACT
Objective. The aim of this study was to investigate the role of hyperlipidemia in the microstructure of parotid gland and its possible amelioration through statin treatment on Wistar rats. Methods. Forty Wistar rats (111.06 ± 3.36 g) were divided into 4 groups (A1, A2 controls, B1, B2 experimental). Groups A1 and A2 consumed normal cereal rodents diet during the experimental hyperlipidemic mixture. The A2 and B2 were treated with simvastatin (Zocor) 40 mg/kg/daily p.o. for 3 months. Results. Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased. The histological findings demonstrated changes in the parotid gland morphology of the B1 and B2, such as the presence of chronic inflammation, fibrosis, lipocytes, and foci of lymphocytic infiltration. Conclusions. The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

No MeSH data available.


Related in: MedlinePlus

In group B2, there were not significant alterations in the cell area or the number and the diameter of the ducts of the parotid gland (haematoxylin eosin—original magnification ×400).
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fig2: In group B2, there were not significant alterations in the cell area or the number and the diameter of the ducts of the parotid gland (haematoxylin eosin—original magnification ×400).

Mentions: Animals of group B2 compared to animals of group A1, revealed statistically insignificant alterations in the cell area, the number and diameter of the ducts (P > .01, Figure 2, Table 2).


Morphological changes of parotid gland in experimental hyperlipidemia.

Daskala ID, Tesseromatis CC - Int J Dent (2011)

In group B2, there were not significant alterations in the cell area or the number and the diameter of the ducts of the parotid gland (haematoxylin eosin—original magnification ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065036&req=5

fig2: In group B2, there were not significant alterations in the cell area or the number and the diameter of the ducts of the parotid gland (haematoxylin eosin—original magnification ×400).
Mentions: Animals of group B2 compared to animals of group A1, revealed statistically insignificant alterations in the cell area, the number and diameter of the ducts (P > .01, Figure 2, Table 2).

Bottom Line: Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased.Conclusions.The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Dentistry, University of Athens, 11527 Goudi, Greece.

ABSTRACT
Objective. The aim of this study was to investigate the role of hyperlipidemia in the microstructure of parotid gland and its possible amelioration through statin treatment on Wistar rats. Methods. Forty Wistar rats (111.06 ± 3.36 g) were divided into 4 groups (A1, A2 controls, B1, B2 experimental). Groups A1 and A2 consumed normal cereal rodents diet during the experimental hyperlipidemic mixture. The A2 and B2 were treated with simvastatin (Zocor) 40 mg/kg/daily p.o. for 3 months. Results. Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased. The histological findings demonstrated changes in the parotid gland morphology of the B1 and B2, such as the presence of chronic inflammation, fibrosis, lipocytes, and foci of lymphocytic infiltration. Conclusions. The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

No MeSH data available.


Related in: MedlinePlus