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Morphological changes of parotid gland in experimental hyperlipidemia.

Daskala ID, Tesseromatis CC - Int J Dent (2011)

Bottom Line: Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased.Conclusions.The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Dentistry, University of Athens, 11527 Goudi, Greece.

ABSTRACT
Objective. The aim of this study was to investigate the role of hyperlipidemia in the microstructure of parotid gland and its possible amelioration through statin treatment on Wistar rats. Methods. Forty Wistar rats (111.06 ± 3.36 g) were divided into 4 groups (A1, A2 controls, B1, B2 experimental). Groups A1 and A2 consumed normal cereal rodents diet during the experimental hyperlipidemic mixture. The A2 and B2 were treated with simvastatin (Zocor) 40 mg/kg/daily p.o. for 3 months. Results. Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased. The histological findings demonstrated changes in the parotid gland morphology of the B1 and B2, such as the presence of chronic inflammation, fibrosis, lipocytes, and foci of lymphocytic infiltration. Conclusions. The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

No MeSH data available.


Related in: MedlinePlus

In group B1, lipid infiltration of the parotid parechyma, presence of lipocytes and nuclei abnormalities (increased cell area and duct's diameter, decreased duct's number) were observed (haematoxylin eosin— original magnification ×400).
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Related In: Results  -  Collection


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fig1: In group B1, lipid infiltration of the parotid parechyma, presence of lipocytes and nuclei abnormalities (increased cell area and duct's diameter, decreased duct's number) were observed (haematoxylin eosin— original magnification ×400).

Mentions: Animals of group B1 compared to animals of group A1, demonstrated a statistically significant increase of cell area and duct's diameter while the duct's number was decreased (P < .001, Figure 1, Table 2).


Morphological changes of parotid gland in experimental hyperlipidemia.

Daskala ID, Tesseromatis CC - Int J Dent (2011)

In group B1, lipid infiltration of the parotid parechyma, presence of lipocytes and nuclei abnormalities (increased cell area and duct's diameter, decreased duct's number) were observed (haematoxylin eosin— original magnification ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065036&req=5

fig1: In group B1, lipid infiltration of the parotid parechyma, presence of lipocytes and nuclei abnormalities (increased cell area and duct's diameter, decreased duct's number) were observed (haematoxylin eosin— original magnification ×400).
Mentions: Animals of group B1 compared to animals of group A1, demonstrated a statistically significant increase of cell area and duct's diameter while the duct's number was decreased (P < .001, Figure 1, Table 2).

Bottom Line: Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased.Conclusions.The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Dentistry, University of Athens, 11527 Goudi, Greece.

ABSTRACT
Objective. The aim of this study was to investigate the role of hyperlipidemia in the microstructure of parotid gland and its possible amelioration through statin treatment on Wistar rats. Methods. Forty Wistar rats (111.06 ± 3.36 g) were divided into 4 groups (A1, A2 controls, B1, B2 experimental). Groups A1 and A2 consumed normal cereal rodents diet during the experimental hyperlipidemic mixture. The A2 and B2 were treated with simvastatin (Zocor) 40 mg/kg/daily p.o. for 3 months. Results. Total cholesterol, triglycerides, high density lipoproteins, and low density lipoproteins were increased in groups B1 and B2 while the parotid weight was decreased. The histological findings demonstrated changes in the parotid gland morphology of the B1 and B2, such as the presence of chronic inflammation, fibrosis, lipocytes, and foci of lymphocytic infiltration. Conclusions. The influence of statin tended to predominate over the chronic inflammation while the lipocytes were decreased and remodelling of the parotid's structure occurred.

No MeSH data available.


Related in: MedlinePlus