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Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases.

Kobawala TP, Patel GH, Gajjar DR, Patel KN, Thakor PB, Parekh UB, Patel KM, Shukla SN, Shah PM - J Thyroid Res (2011)

Bottom Line: Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals.IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients.Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular Endocrinology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India.

ABSTRACT
Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.

No MeSH data available.


Related in: MedlinePlus

ROC curves for IL-8 and IFN-α.
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fig1: ROC curves for IL-8 and IFN-α.

Mentions: ROC curve (Figure 1(a)) indicates that both IL-8 and IFN-α exhibited a good discriminatory efficacy between healthy individuals and total patients with thyroid diseases (IL-8: AUC-0.756; IFN-α: AUC-0.795). Moreover, the ROC curves for both the cytokines between healthy individuals and individual groups of patients, that is, goiter, autoimmune disease, and thyroid cancer, revealed that both IL-8 as well as IFN-α showed good sensitivity and specificity to discriminate between healthy individuals and patients having different thyroid diseases (goiter- IL-8: AUC-0.774, IFN-α: AUC-0.797; autoimmune thyroid disease- IL-8: AUC-0.711, IFN-α: AUC-0.755, and thyroid cancer- IL-8: AUC-0.767, IFN-α: AUC-0.813) (Figures 1(b)–1(d)). Only IL-8 could significantly discriminate between early- and advanced-stage thyroid cancer patients (Figure 1(e)).


Clinical utility of serum interleukin-8 and interferon-alpha in thyroid diseases.

Kobawala TP, Patel GH, Gajjar DR, Patel KN, Thakor PB, Parekh UB, Patel KM, Shukla SN, Shah PM - J Thyroid Res (2011)

ROC curves for IL-8 and IFN-α.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3065012&req=5

fig1: ROC curves for IL-8 and IFN-α.
Mentions: ROC curve (Figure 1(a)) indicates that both IL-8 and IFN-α exhibited a good discriminatory efficacy between healthy individuals and total patients with thyroid diseases (IL-8: AUC-0.756; IFN-α: AUC-0.795). Moreover, the ROC curves for both the cytokines between healthy individuals and individual groups of patients, that is, goiter, autoimmune disease, and thyroid cancer, revealed that both IL-8 as well as IFN-α showed good sensitivity and specificity to discriminate between healthy individuals and patients having different thyroid diseases (goiter- IL-8: AUC-0.774, IFN-α: AUC-0.797; autoimmune thyroid disease- IL-8: AUC-0.711, IFN-α: AUC-0.755, and thyroid cancer- IL-8: AUC-0.767, IFN-α: AUC-0.813) (Figures 1(b)–1(d)). Only IL-8 could significantly discriminate between early- and advanced-stage thyroid cancer patients (Figure 1(e)).

Bottom Line: Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals.IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients.Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular Endocrinology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India.

ABSTRACT
Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.

No MeSH data available.


Related in: MedlinePlus