Proximal femur structural geometry changes during and following lactation.
Bottom Line: Human lactation is associated with transient decreases in bone mineral density (BMD).Adjusting for weight changes decreased the magnitude and significance of HSA changes at peak-lactation and by post-lactation there were no significant differences from 2 weeks postpartum.In conclusion, lactation is associated with significant but transient changes in hip BMD and structural geometry.
Affiliation: MRC Human Nutrition Research, Cambridge, UK. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Bone mineral measurements on the left hip were performed using DXA (QDR-1000W; Hologic Inc, Bedford, MA). Hip scans were analysed using the hip structural analysis (HSA) program (version 1) . This is a computational algorithm applied to 2-D projected images of the hip generated from DXA scans, following conventional bone mineral analysis. The program uses the distribution of mineral mass in a line of pixels across the bone axis to compute cross-sectional structural geometry outcomes (e.g., CSA) in cut planes traversing the bone at three specific locations. These locations are: the narrow neck (region of interest [ROI] of 3-mm width, at the narrowest portion of femoral neck), intertrochanter (ROI of 3-mm width, along the bisector of the neck-shaft angle) and proximal shaft (ROI of 3-mm width, through the femoral shaft and located 2 cm distal to the user-defined midpoint of the lesser trochanter) as shown in Fig. 1. The narrow neck region approximates to the femoral neck region reported for conventional DXA scans, though lying proximal to it for Hologic machines. There are no conventional DXA-equivalent regions for intertrochanteric and shaft HSA regions.
Affiliation: MRC Human Nutrition Research, Cambridge, UK. firstname.lastname@example.org