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A comparative protein function analysis databaseof different Leishmania strains.

Dikhit MR, Nathasharma YP, Patel L, Rana SP, Sahoo GC, Das P - Bioinformation (2011)

Bottom Line: The database facilitates significant relationship between template information and possible protein functional families assigned to different proteins by SVMProt.A specific characterization information table provides information related to species and specific functional families.This database aims to be a resource for scientists working on proteomics.

View Article: PubMed Central - PubMed

Affiliation: BioMedical Informatics Division, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Agam kuan, Patna-800007, India.

ABSTRACT
A complete understanding of different protein functional families and template information opens new avenues for novel drug development. Protein identification and analysis software performs a central role in the investigation of proteins and leads to the development of refined database for description of proteins of different Leishmania strains. There are certain databases for different strains that lack template information and functional family annotation. Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) has developed a web-based unique database to provide information about functional families of different proteins and its template information in different Leishmania species. Based on the template information users can model the tertiary structure of protein. The database facilitates significant relationship between template information and possible protein functional families assigned to different proteins by SVMProt. This database is designed to provide comprehensive descriptions of certain important proteins found in four different species of Leishmania i.e. L. donovani, L. infantum, L. major and L. braziliensis. A specific characterization information table provides information related to species and specific functional families. This database aims to be a resource for scientists working on proteomics. The database is freely available at http://biomedinformri.org/calp/.

No MeSH data available.


Related in: MedlinePlus

Typical screenshots of the Database showing the functional family oftwo compared protein with Database id, species name and protein name.
© Copyright Policy - open-access
Related In: Results  -  Collection


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Figure 2: Typical screenshots of the Database showing the functional family oftwo compared protein with Database id, species name and protein name.

Mentions: The data/information store in database can be accessed in very simple way likeSearch by species name and protein functional family: The user can enter thedesired species name to access the common protein present in other strain ofthat species e.g. if somebody enter the sp. name L.donovani then it will showall protein of L.donovani which is also present in other three strain i.e. L.major,L.infantum and L. braziliensis).The user can select the different proteinfunctional family to find out the proteins that possesses the same function(Figure 2). The user can compare the proteins of different species and theirfunctional families. The user can also compare tertiary structure of thetemplates (Figure 3).


A comparative protein function analysis databaseof different Leishmania strains.

Dikhit MR, Nathasharma YP, Patel L, Rana SP, Sahoo GC, Das P - Bioinformation (2011)

Typical screenshots of the Database showing the functional family oftwo compared protein with Database id, species name and protein name.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3064847&req=5

Figure 2: Typical screenshots of the Database showing the functional family oftwo compared protein with Database id, species name and protein name.
Mentions: The data/information store in database can be accessed in very simple way likeSearch by species name and protein functional family: The user can enter thedesired species name to access the common protein present in other strain ofthat species e.g. if somebody enter the sp. name L.donovani then it will showall protein of L.donovani which is also present in other three strain i.e. L.major,L.infantum and L. braziliensis).The user can select the different proteinfunctional family to find out the proteins that possesses the same function(Figure 2). The user can compare the proteins of different species and theirfunctional families. The user can also compare tertiary structure of thetemplates (Figure 3).

Bottom Line: The database facilitates significant relationship between template information and possible protein functional families assigned to different proteins by SVMProt.A specific characterization information table provides information related to species and specific functional families.This database aims to be a resource for scientists working on proteomics.

View Article: PubMed Central - PubMed

Affiliation: BioMedical Informatics Division, Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Agam kuan, Patna-800007, India.

ABSTRACT
A complete understanding of different protein functional families and template information opens new avenues for novel drug development. Protein identification and analysis software performs a central role in the investigation of proteins and leads to the development of refined database for description of proteins of different Leishmania strains. There are certain databases for different strains that lack template information and functional family annotation. Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) has developed a web-based unique database to provide information about functional families of different proteins and its template information in different Leishmania species. Based on the template information users can model the tertiary structure of protein. The database facilitates significant relationship between template information and possible protein functional families assigned to different proteins by SVMProt. This database is designed to provide comprehensive descriptions of certain important proteins found in four different species of Leishmania i.e. L. donovani, L. infantum, L. major and L. braziliensis. A specific characterization information table provides information related to species and specific functional families. This database aims to be a resource for scientists working on proteomics. The database is freely available at http://biomedinformri.org/calp/.

No MeSH data available.


Related in: MedlinePlus