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Diffusion tensor imaging differences relate to memory deficits in diffuse traumatic brain injury.

Palacios EM, Fernandez-Espejo D, Junque C, Sanchez-Carrion R, Roig T, Tormos JM, Bargallo N, Vendrell P - BMC Neurol (2011)

Bottom Line: Whole brain DTI analysis showed a global decrease in FA values that correlated with the 2-back d-prime index, but not with the Rivermead profile.ROI analysis revealed positive correlations between working memory performance assessed by 2-back d-prime and superior longitudinal fasciculi, corpus callosum, arcuate fasciculi and fornix.Diffuse TBI is associated with a general decrease of white matter integrity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.

ABSTRACT

Background: Memory is one of the most impaired functions after traumatic brain injury (TBI). We used diffusion tensor imaging (DTI) to determine the structural basis of memory deficit. We correlated fractional anisotropy (FA) of the fasciculi connecting the main cerebral regions that are involved in declarative and working memory functions.

Methods: Fifteen patients with severe and diffuse TBI and sixteen healthy controls matched by age and years of education were scanned. The neuropsychological assessment included: Letter-number sequencing test (LNS), 2-back task, digit span (forwards and backwards) and the Rivermead profilet. DTI was analyzed by a tract-based spatial statics (TBSS) approach.

Results: Whole brain DTI analysis showed a global decrease in FA values that correlated with the 2-back d-prime index, but not with the Rivermead profile. ROI analysis revealed positive correlations between working memory performance assessed by 2-back d-prime and superior longitudinal fasciculi, corpus callosum, arcuate fasciculi and fornix. Declarative memory assessed by the Rivermead profile scores correlated with the fornix and the corpus callosum.

Conclusions: Diffuse TBI is associated with a general decrease of white matter integrity. Nevertheless deficits in specific memory domains are related to different patterns of white matter damage.

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Related in: MedlinePlus

ROI correlations with RBMT in the TBI group: RBMT correlated with the fornix and the corpus callosum ROIs (TFCE, p < 0.05 FWE-corrected). Correlation coefficient (r) was directly converted from t values of the TBSS output. The t and r values correspond to the most statistically significant voxel for each cluster.
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Figure 3: ROI correlations with RBMT in the TBI group: RBMT correlated with the fornix and the corpus callosum ROIs (TFCE, p < 0.05 FWE-corrected). Correlation coefficient (r) was directly converted from t values of the TBSS output. The t and r values correspond to the most statistically significant voxel for each cluster.

Mentions: The ROI procedure revealed a positive correlation between working memory performance assessed by the 2-back d- index and the FA skeletonized SLF, fornix, and corpus callosum ROIs (Figure 2, Table 5). 2-back d-prime index also correlated with the arcuate fascicle (Table 5). Declarative memory performance, assessed by RBMT, correlated with the fornix and the posterior part of the corpus callosum ROIs (Figure 3, Table 5).


Diffusion tensor imaging differences relate to memory deficits in diffuse traumatic brain injury.

Palacios EM, Fernandez-Espejo D, Junque C, Sanchez-Carrion R, Roig T, Tormos JM, Bargallo N, Vendrell P - BMC Neurol (2011)

ROI correlations with RBMT in the TBI group: RBMT correlated with the fornix and the corpus callosum ROIs (TFCE, p < 0.05 FWE-corrected). Correlation coefficient (r) was directly converted from t values of the TBSS output. The t and r values correspond to the most statistically significant voxel for each cluster.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3050687&req=5

Figure 3: ROI correlations with RBMT in the TBI group: RBMT correlated with the fornix and the corpus callosum ROIs (TFCE, p < 0.05 FWE-corrected). Correlation coefficient (r) was directly converted from t values of the TBSS output. The t and r values correspond to the most statistically significant voxel for each cluster.
Mentions: The ROI procedure revealed a positive correlation between working memory performance assessed by the 2-back d- index and the FA skeletonized SLF, fornix, and corpus callosum ROIs (Figure 2, Table 5). 2-back d-prime index also correlated with the arcuate fascicle (Table 5). Declarative memory performance, assessed by RBMT, correlated with the fornix and the posterior part of the corpus callosum ROIs (Figure 3, Table 5).

Bottom Line: Whole brain DTI analysis showed a global decrease in FA values that correlated with the 2-back d-prime index, but not with the Rivermead profile.ROI analysis revealed positive correlations between working memory performance assessed by 2-back d-prime and superior longitudinal fasciculi, corpus callosum, arcuate fasciculi and fornix.Diffuse TBI is associated with a general decrease of white matter integrity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.

ABSTRACT

Background: Memory is one of the most impaired functions after traumatic brain injury (TBI). We used diffusion tensor imaging (DTI) to determine the structural basis of memory deficit. We correlated fractional anisotropy (FA) of the fasciculi connecting the main cerebral regions that are involved in declarative and working memory functions.

Methods: Fifteen patients with severe and diffuse TBI and sixteen healthy controls matched by age and years of education were scanned. The neuropsychological assessment included: Letter-number sequencing test (LNS), 2-back task, digit span (forwards and backwards) and the Rivermead profilet. DTI was analyzed by a tract-based spatial statics (TBSS) approach.

Results: Whole brain DTI analysis showed a global decrease in FA values that correlated with the 2-back d-prime index, but not with the Rivermead profile. ROI analysis revealed positive correlations between working memory performance assessed by 2-back d-prime and superior longitudinal fasciculi, corpus callosum, arcuate fasciculi and fornix. Declarative memory assessed by the Rivermead profile scores correlated with the fornix and the corpus callosum.

Conclusions: Diffuse TBI is associated with a general decrease of white matter integrity. Nevertheless deficits in specific memory domains are related to different patterns of white matter damage.

Show MeSH
Related in: MedlinePlus