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The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design.

López-Cancio E, Dorado L, Millán M, Reverté S, Suñol A, Massuet A, Mataró M, Galán A, Alzamora M, Pera G, Torán P, Dávalos A, Arenillas JF - BMC Neurol (2011)

Bottom Line: A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied.Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA.A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosciences, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain. elenacancio@gmail.com

ABSTRACT

Background: Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition.

Methods/design: Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events.

Discussion: The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.

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Related in: MedlinePlus

ASIA study flow chart. The diagram shows baseline procedures and follow-up in ASIA study. Subjects with asymptomatic intracranial atherostenoses (ASIA) in basal ultrasound study will undergo a Magnetic Resonance Angiograph (MRA) and will be followed annually in our centre. Two years after inclusion a new duplex and NPS (neuropsychological) study will be performed. Subjects without ASIA will be followed in PERART study.
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Figure 2: ASIA study flow chart. The diagram shows baseline procedures and follow-up in ASIA study. Subjects with asymptomatic intracranial atherostenoses (ASIA) in basal ultrasound study will undergo a Magnetic Resonance Angiograph (MRA) and will be followed annually in our centre. Two years after inclusion a new duplex and NPS (neuropsychological) study will be performed. Subjects without ASIA will be followed in PERART study.

Mentions: ASIA study sample selection. The diagram shows the sample selection in ASIA study from the reference population. SIAP system: Primary Care Information Technology System; sbj: subjects; AAI: ankle-arm index; CD: coronary disease.


The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design.

López-Cancio E, Dorado L, Millán M, Reverté S, Suñol A, Massuet A, Mataró M, Galán A, Alzamora M, Pera G, Torán P, Dávalos A, Arenillas JF - BMC Neurol (2011)

ASIA study flow chart. The diagram shows baseline procedures and follow-up in ASIA study. Subjects with asymptomatic intracranial atherostenoses (ASIA) in basal ultrasound study will undergo a Magnetic Resonance Angiograph (MRA) and will be followed annually in our centre. Two years after inclusion a new duplex and NPS (neuropsychological) study will be performed. Subjects without ASIA will be followed in PERART study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3050686&req=5

Figure 2: ASIA study flow chart. The diagram shows baseline procedures and follow-up in ASIA study. Subjects with asymptomatic intracranial atherostenoses (ASIA) in basal ultrasound study will undergo a Magnetic Resonance Angiograph (MRA) and will be followed annually in our centre. Two years after inclusion a new duplex and NPS (neuropsychological) study will be performed. Subjects without ASIA will be followed in PERART study.
Mentions: ASIA study sample selection. The diagram shows the sample selection in ASIA study from the reference population. SIAP system: Primary Care Information Technology System; sbj: subjects; AAI: ankle-arm index; CD: coronary disease.

Bottom Line: A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied.Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA.A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosciences, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain. elenacancio@gmail.com

ABSTRACT

Background: Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition.

Methods/design: Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events.

Discussion: The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.

Show MeSH
Related in: MedlinePlus