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Are quantum dots ready for in vivo imaging in human subjects?

Cai W, Hsu AR, Li ZB, Chen X - Nanoscale Res Lett (2007)

Bottom Line: Numerous studies on QDs have resulted in major advancements in QD surface modification, coating, biocompatibility, sensitivity, multiplexing, targeting specificity, as well as important findings regarding toxicity and applicability.For in vitro applications, QDs can be used in place of traditional organic fluorescent dyes in virtually any system, outperforming organic dyes in the majority of cases.With new advances in QD technology such as bioluminescence resonance energy transfer, synthesis of smaller size non-Cd based QDs, improved surface coating and conjugation, and multifunctional probes for multimodality imaging, it is likely that human applications of QDs will soon be possible in a clinical setting.

View Article: PubMed Central - PubMed

Affiliation: The Molecular Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USA.

ABSTRACT
Nanotechnology has the potential to profoundly transform the nature of cancer diagnosis and cancer patient management in the future. Over the past decade, quantum dots (QDs) have become one of the fastest growing areas of research in nanotechnology. QDs are fluorescent semiconductor nanoparticles suitable for multiplexed in vitro and in vivo imaging. Numerous studies on QDs have resulted in major advancements in QD surface modification, coating, biocompatibility, sensitivity, multiplexing, targeting specificity, as well as important findings regarding toxicity and applicability. For in vitro applications, QDs can be used in place of traditional organic fluorescent dyes in virtually any system, outperforming organic dyes in the majority of cases. In vivo targeted tumor imaging with biocompatible QDs has recently become possible in mouse models. With new advances in QD technology such as bioluminescence resonance energy transfer, synthesis of smaller size non-Cd based QDs, improved surface coating and conjugation, and multifunctional probes for multimodality imaging, it is likely that human applications of QDs will soon be possible in a clinical setting.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of the formation of dendron-coated QDs. From [195]
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Figure 11: Schematic illustration of the formation of dendron-coated QDs. From [195]

Mentions: Dendron-coated QDs have high stability, versatility, and chemical/biochemical proccessibility [194,195]. Unlike the typical polymer coating, dendron-ligands are tight and small in radial dimension, resulting in an overall smaller size of QDs (Fig. 11). The surface density and length of the PEG units on the outer surface of the resulting dendron-coated QDs can be varied by synthesizing dendron ligands with different terminal structures. A “peptide toolkit” has been reported which can provide a straightforward means for improving biocompatibility for cell biology and in vivo applications [47]. In the future, it is likely that small molecule or peptide-coated QDs will have better opportunities for development and expansion in in vivo applications than protein or antibody-conjugated QDs.


Are quantum dots ready for in vivo imaging in human subjects?

Cai W, Hsu AR, Li ZB, Chen X - Nanoscale Res Lett (2007)

Schematic illustration of the formation of dendron-coated QDs. From [195]
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3050636&req=5

Figure 11: Schematic illustration of the formation of dendron-coated QDs. From [195]
Mentions: Dendron-coated QDs have high stability, versatility, and chemical/biochemical proccessibility [194,195]. Unlike the typical polymer coating, dendron-ligands are tight and small in radial dimension, resulting in an overall smaller size of QDs (Fig. 11). The surface density and length of the PEG units on the outer surface of the resulting dendron-coated QDs can be varied by synthesizing dendron ligands with different terminal structures. A “peptide toolkit” has been reported which can provide a straightforward means for improving biocompatibility for cell biology and in vivo applications [47]. In the future, it is likely that small molecule or peptide-coated QDs will have better opportunities for development and expansion in in vivo applications than protein or antibody-conjugated QDs.

Bottom Line: Numerous studies on QDs have resulted in major advancements in QD surface modification, coating, biocompatibility, sensitivity, multiplexing, targeting specificity, as well as important findings regarding toxicity and applicability.For in vitro applications, QDs can be used in place of traditional organic fluorescent dyes in virtually any system, outperforming organic dyes in the majority of cases.With new advances in QD technology such as bioluminescence resonance energy transfer, synthesis of smaller size non-Cd based QDs, improved surface coating and conjugation, and multifunctional probes for multimodality imaging, it is likely that human applications of QDs will soon be possible in a clinical setting.

View Article: PubMed Central - PubMed

Affiliation: The Molecular Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, 1201 Welch Rd, P095, Stanford, CA 94305-5484, USA.

ABSTRACT
Nanotechnology has the potential to profoundly transform the nature of cancer diagnosis and cancer patient management in the future. Over the past decade, quantum dots (QDs) have become one of the fastest growing areas of research in nanotechnology. QDs are fluorescent semiconductor nanoparticles suitable for multiplexed in vitro and in vivo imaging. Numerous studies on QDs have resulted in major advancements in QD surface modification, coating, biocompatibility, sensitivity, multiplexing, targeting specificity, as well as important findings regarding toxicity and applicability. For in vitro applications, QDs can be used in place of traditional organic fluorescent dyes in virtually any system, outperforming organic dyes in the majority of cases. In vivo targeted tumor imaging with biocompatible QDs has recently become possible in mouse models. With new advances in QD technology such as bioluminescence resonance energy transfer, synthesis of smaller size non-Cd based QDs, improved surface coating and conjugation, and multifunctional probes for multimodality imaging, it is likely that human applications of QDs will soon be possible in a clinical setting.

No MeSH data available.


Related in: MedlinePlus