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Control of viral replication after cessation of HAART.

Van Gulck E, Heyndrickx L, Bracke L, Coppens S, Florence E, Buvé A, Lewi P, Vanham G - AIDS Res Ther (2011)

Bottom Line: We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease.CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control.But their viruses are clearly less fit compared to viruses from rebounders.

View Article: PubMed Central - HTML - PubMed

Affiliation: Virology unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp (ITMA), Antwerp, Belgium. evangulck@itg.be.

ABSTRACT
We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders.

No MeSH data available.


Related in: MedlinePlus

Relative replication fitness. The relative replication fitness was determined in PHA blasts from 3 healthy donors by measuring the p24 production produced by HIV reference strains BAL and IIIB or patient viruses (P1 is secondary controller, P5-P8 is from rebounders). (A): p24 production in ng/ml in donor 1. (B): p24 production in ng/ml in donor 2. (C): p24 production in ng/ml in donor 3.
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Figure 1: Relative replication fitness. The relative replication fitness was determined in PHA blasts from 3 healthy donors by measuring the p24 production produced by HIV reference strains BAL and IIIB or patient viruses (P1 is secondary controller, P5-P8 is from rebounders). (A): p24 production in ng/ml in donor 1. (B): p24 production in ng/ml in donor 2. (C): p24 production in ng/ml in donor 3.

Mentions: Autologous viruses from patient 1 could be cultured making it possible to investigate whether the virus of this patient was less fit in comparison to reference strains or virus of 4 different rebounders. Figure 1 clearly shows that the virus of the SC replicates less as compared to the reference strains and viruses of rebounders since the amount of p24 produced in PHA stimulated PBMC remains much lower over time in comparison to viruses of rebounders and the reference strain.


Control of viral replication after cessation of HAART.

Van Gulck E, Heyndrickx L, Bracke L, Coppens S, Florence E, Buvé A, Lewi P, Vanham G - AIDS Res Ther (2011)

Relative replication fitness. The relative replication fitness was determined in PHA blasts from 3 healthy donors by measuring the p24 production produced by HIV reference strains BAL and IIIB or patient viruses (P1 is secondary controller, P5-P8 is from rebounders). (A): p24 production in ng/ml in donor 1. (B): p24 production in ng/ml in donor 2. (C): p24 production in ng/ml in donor 3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3046910&req=5

Figure 1: Relative replication fitness. The relative replication fitness was determined in PHA blasts from 3 healthy donors by measuring the p24 production produced by HIV reference strains BAL and IIIB or patient viruses (P1 is secondary controller, P5-P8 is from rebounders). (A): p24 production in ng/ml in donor 1. (B): p24 production in ng/ml in donor 2. (C): p24 production in ng/ml in donor 3.
Mentions: Autologous viruses from patient 1 could be cultured making it possible to investigate whether the virus of this patient was less fit in comparison to reference strains or virus of 4 different rebounders. Figure 1 clearly shows that the virus of the SC replicates less as compared to the reference strains and viruses of rebounders since the amount of p24 produced in PHA stimulated PBMC remains much lower over time in comparison to viruses of rebounders and the reference strain.

Bottom Line: We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease.CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control.But their viruses are clearly less fit compared to viruses from rebounders.

View Article: PubMed Central - HTML - PubMed

Affiliation: Virology unit, Department of Microbiology, Institute of Tropical Medicine, Antwerp (ITMA), Antwerp, Belgium. evangulck@itg.be.

ABSTRACT
We describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the other, despite apparent viral control. We failed to identify any immune activation or genetic markers that could offer an explanation for this unusual "secondary controller" status. But their viruses are clearly less fit compared to viruses from rebounders.

No MeSH data available.


Related in: MedlinePlus