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Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss.

Garaulet M, Sánchez-Moreno C, Smith CE, Lee YC, Nicolás F, Ordovás JM - PLoS ONE (2011)

Bottom Line: Specifically, carriers of the minor C allele were more resistant to weight loss than TT individuals (Mean±SEM) (8.71±0.59 kg vs 10.4±0.57 kg) C and TT respectively.Sleep reduction, changes in ghrelin values, alterations of eating behaviors and evening preference that characterized CLOCK 3111C carriers could be affecting weight loss.Our results support the hypothesis that the influence of the CLOCK gene may extend to a broad range of variables linked with human behaviors.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain. garaulet@um.es

ABSTRACT

Background: Circadian Locomotor Output Cycles Kaput (CLOCK), an essential element of the positive regulatory arm in the human biological clock, is involved in metabolic regulation. The aim was to investigate the behavioral (sleep duration, eating patterns and chronobiological characteristics) and hormonal (plasma ghrelin and leptin concentrations) factors which could explain the previously reported association between the CLOCK 3111T/C SNP and weight loss.

Methodology/principal findings: We recruited 1495 overweight/obese subjects (BMI: 25-40 kg/m(2)) of 20-65 y. who attended outpatient obesity clinics in Murcia, in southeastern Spain. We detected an association between the CLOCK 3111T/C SNP and weight loss, which was particularly evident after 12-14 weeks of treatment (P = 0.038). Specifically, carriers of the minor C allele were more resistant to weight loss than TT individuals (Mean±SEM) (8.71±0.59 kg vs 10.4±0.57 kg) C and TT respectively. In addition, our data show that minor C allele carriers had: 1. shorter sleep duration Mean ± SEM (7.0±0.05 vs 7.3±0.05) C and TT respectively (P = 0.039), 2. higher plasma ghrelin concentrations Mean ± SEM (pg/ml) (1108±49 vs 976±47)(P = 0.034); 3. delayed breakfast time; 4. evening preference and 5. less compliance with a Mediterranean Diet pattern, as compared with TT homozygotes.

Conclusions/significance: Sleep reduction, changes in ghrelin values, alterations of eating behaviors and evening preference that characterized CLOCK 3111C carriers could be affecting weight loss. Our results support the hypothesis that the influence of the CLOCK gene may extend to a broad range of variables linked with human behaviors.

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Related in: MedlinePlus

CLOCK 3111T/C genotype and weight loss progression during 28 weeks of treatment.
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pone-0017435-g001: CLOCK 3111T/C genotype and weight loss progression during 28 weeks of treatment.

Mentions: We found an association between the CLOCK 3111T/C SNP and weight loss. Subjects carrying the minor C allele lost significantly less weight (Mean±SEM) (8.71±0.59 kg) compared to TT subjects (10.4±0.57 kg). This effect was particularly evident after 16 weeks of treatment (P = 0.038) (Figure 1). When patients were divided into low and high groups according to median age, differences in weight loss among C and TT carriers were only significant in the older group (≥38 y.) (P = 0.035) while differences were not significant in the younger group (P = 0.297).


Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss.

Garaulet M, Sánchez-Moreno C, Smith CE, Lee YC, Nicolás F, Ordovás JM - PLoS ONE (2011)

CLOCK 3111T/C genotype and weight loss progression during 28 weeks of treatment.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3046145&req=5

pone-0017435-g001: CLOCK 3111T/C genotype and weight loss progression during 28 weeks of treatment.
Mentions: We found an association between the CLOCK 3111T/C SNP and weight loss. Subjects carrying the minor C allele lost significantly less weight (Mean±SEM) (8.71±0.59 kg) compared to TT subjects (10.4±0.57 kg). This effect was particularly evident after 16 weeks of treatment (P = 0.038) (Figure 1). When patients were divided into low and high groups according to median age, differences in weight loss among C and TT carriers were only significant in the older group (≥38 y.) (P = 0.035) while differences were not significant in the younger group (P = 0.297).

Bottom Line: Specifically, carriers of the minor C allele were more resistant to weight loss than TT individuals (Mean±SEM) (8.71±0.59 kg vs 10.4±0.57 kg) C and TT respectively.Sleep reduction, changes in ghrelin values, alterations of eating behaviors and evening preference that characterized CLOCK 3111C carriers could be affecting weight loss.Our results support the hypothesis that the influence of the CLOCK gene may extend to a broad range of variables linked with human behaviors.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain. garaulet@um.es

ABSTRACT

Background: Circadian Locomotor Output Cycles Kaput (CLOCK), an essential element of the positive regulatory arm in the human biological clock, is involved in metabolic regulation. The aim was to investigate the behavioral (sleep duration, eating patterns and chronobiological characteristics) and hormonal (plasma ghrelin and leptin concentrations) factors which could explain the previously reported association between the CLOCK 3111T/C SNP and weight loss.

Methodology/principal findings: We recruited 1495 overweight/obese subjects (BMI: 25-40 kg/m(2)) of 20-65 y. who attended outpatient obesity clinics in Murcia, in southeastern Spain. We detected an association between the CLOCK 3111T/C SNP and weight loss, which was particularly evident after 12-14 weeks of treatment (P = 0.038). Specifically, carriers of the minor C allele were more resistant to weight loss than TT individuals (Mean±SEM) (8.71±0.59 kg vs 10.4±0.57 kg) C and TT respectively. In addition, our data show that minor C allele carriers had: 1. shorter sleep duration Mean ± SEM (7.0±0.05 vs 7.3±0.05) C and TT respectively (P = 0.039), 2. higher plasma ghrelin concentrations Mean ± SEM (pg/ml) (1108±49 vs 976±47)(P = 0.034); 3. delayed breakfast time; 4. evening preference and 5. less compliance with a Mediterranean Diet pattern, as compared with TT homozygotes.

Conclusions/significance: Sleep reduction, changes in ghrelin values, alterations of eating behaviors and evening preference that characterized CLOCK 3111C carriers could be affecting weight loss. Our results support the hypothesis that the influence of the CLOCK gene may extend to a broad range of variables linked with human behaviors.

Show MeSH
Related in: MedlinePlus