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Impulsivity and the 5-HTTLPR polymorphism in a non-clinical sample.

Lage GM, Malloy-Diniz LF, Matos LO, Bastos MA, Abrantes SS, Corrêa H - PLoS ONE (2011)

Bottom Line: Impulsivity has been associated with serotonergic system functions.Then, these participants were grouped by genotype and gender, and their scores on impulsivity measures were compared.There were no significant differences between group scores on attentional, motor and non-planning impulsivity.

View Article: PubMed Central - PubMed

Affiliation: College of Human, Social and Health Sciences, FUMEC University, Belo Horizonte, Minas Gerais, Brazil. menezeslage@gmail.com

ABSTRACT

Background: Impulsivity has been associated with serotonergic system functions. However, few researchers have investigated the relationship between a polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) and the different components of impulsivity in a non-clinical population. The aim of this study was to investigate the relationship between a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and the different components of impulsivity in a non-clinical population.

Methodology/principal findings: We administered two neuropsychological tests, the Continuous Performance Task and the Iowa Gambling Task, to 127 healthy participants to measure their levels of motor, attentional and non-planning impulsivity. Then, these participants were grouped by genotype and gender, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional, motor and non-planning impulsivity.

Conclusions/significance: Our results suggest that 5-HTTLPR genotype is not significantly associated with subsets of impulsive behavior in a non-clinical sample when measured by neuropsychological tests. These findings are discussed in terms of the sensitivity of neuropsychological tests to detect impulsivity in a non-clinical population and the role of gender and race in the relationship between the 5-HTTLPR and impulsivity.

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Non-planning impulsivity scores and standard deviation of scores by gender and genotype.
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pone-0016927-g003: Non-planning impulsivity scores and standard deviation of scores by gender and genotype.

Mentions: For both genders, we compared individuals with LL genotypes to individuals carrying an S-allele (LS + SS genotypes) using Student's t-tests and Mann-Whitney U tests. The analyses of females groups did not show differences in attentional (Z = 11.57, p = 0.11), motor (t (73) = 0.335, p = 0.72) and non-planning [t (73) = 0.63, p = 0.87) impulsivity. The same pattern of results was found in the analyses of male groups. No differences were found in attentional (Z = −0.316, p = 0.75), motor [t (50) = 0.01, p = 0.98) and non-planning [t (50) = −0.17, p = 0.86) impulsivity. The means and standard deviation of means of the impulsivity scores for females and males are presented in Figures 1, 2, and 3.


Impulsivity and the 5-HTTLPR polymorphism in a non-clinical sample.

Lage GM, Malloy-Diniz LF, Matos LO, Bastos MA, Abrantes SS, Corrêa H - PLoS ONE (2011)

Non-planning impulsivity scores and standard deviation of scores by gender and genotype.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3046116&req=5

pone-0016927-g003: Non-planning impulsivity scores and standard deviation of scores by gender and genotype.
Mentions: For both genders, we compared individuals with LL genotypes to individuals carrying an S-allele (LS + SS genotypes) using Student's t-tests and Mann-Whitney U tests. The analyses of females groups did not show differences in attentional (Z = 11.57, p = 0.11), motor (t (73) = 0.335, p = 0.72) and non-planning [t (73) = 0.63, p = 0.87) impulsivity. The same pattern of results was found in the analyses of male groups. No differences were found in attentional (Z = −0.316, p = 0.75), motor [t (50) = 0.01, p = 0.98) and non-planning [t (50) = −0.17, p = 0.86) impulsivity. The means and standard deviation of means of the impulsivity scores for females and males are presented in Figures 1, 2, and 3.

Bottom Line: Impulsivity has been associated with serotonergic system functions.Then, these participants were grouped by genotype and gender, and their scores on impulsivity measures were compared.There were no significant differences between group scores on attentional, motor and non-planning impulsivity.

View Article: PubMed Central - PubMed

Affiliation: College of Human, Social and Health Sciences, FUMEC University, Belo Horizonte, Minas Gerais, Brazil. menezeslage@gmail.com

ABSTRACT

Background: Impulsivity has been associated with serotonergic system functions. However, few researchers have investigated the relationship between a polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) and the different components of impulsivity in a non-clinical population. The aim of this study was to investigate the relationship between a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and the different components of impulsivity in a non-clinical population.

Methodology/principal findings: We administered two neuropsychological tests, the Continuous Performance Task and the Iowa Gambling Task, to 127 healthy participants to measure their levels of motor, attentional and non-planning impulsivity. Then, these participants were grouped by genotype and gender, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional, motor and non-planning impulsivity.

Conclusions/significance: Our results suggest that 5-HTTLPR genotype is not significantly associated with subsets of impulsive behavior in a non-clinical sample when measured by neuropsychological tests. These findings are discussed in terms of the sensitivity of neuropsychological tests to detect impulsivity in a non-clinical population and the role of gender and race in the relationship between the 5-HTTLPR and impulsivity.

Show MeSH