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Cancer drug promotes axon regeneration

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Hellal et al. therefore investigated whether Taxol, a microtubule-stabilising drug that is widely used in cancer therapy to limit cell division, could reduce these effects following spinal cord injury (SCI)... In rats, application of a low dose of Taxol at the site of SCI interfered with mechanisms important for scar formation, such as TGFβ signalling, transduction of which requires the microtubule network... In addition to decreasing scar formation, Taxol treatment reduced the amount of growth-inhibitory chondroitin sulfate proteoglycans at the lesion site, which together created an environment conducive to axon growth... Moreover, Taxol treatment induced axon regeneration, resulting in functional improvement... UmlaufM... KapiteinL... StrikisD... LemmonV... BixbyJ. (2011)... Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.

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Confocal image of a fibrotic scar, a major obstacle to axon regeneration, in a lesioned rat spinal cord. Image provided courtesy of F. Hellal and F. Bradke, Max Planck Institute of Neurobiology.
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f1-0040136a: Confocal image of a fibrotic scar, a major obstacle to axon regeneration, in a lesioned rat spinal cord. Image provided courtesy of F. Hellal and F. Bradke, Max Planck Institute of Neurobiology.


Cancer drug promotes axon regeneration
Confocal image of a fibrotic scar, a major obstacle to axon regeneration, in a lesioned rat spinal cord. Image provided courtesy of F. Hellal and F. Bradke, Max Planck Institute of Neurobiology.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3046080&req=5

f1-0040136a: Confocal image of a fibrotic scar, a major obstacle to axon regeneration, in a lesioned rat spinal cord. Image provided courtesy of F. Hellal and F. Bradke, Max Planck Institute of Neurobiology.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Hellal et al. therefore investigated whether Taxol, a microtubule-stabilising drug that is widely used in cancer therapy to limit cell division, could reduce these effects following spinal cord injury (SCI)... In rats, application of a low dose of Taxol at the site of SCI interfered with mechanisms important for scar formation, such as TGFβ signalling, transduction of which requires the microtubule network... In addition to decreasing scar formation, Taxol treatment reduced the amount of growth-inhibitory chondroitin sulfate proteoglycans at the lesion site, which together created an environment conducive to axon growth... Moreover, Taxol treatment induced axon regeneration, resulting in functional improvement... UmlaufM... KapiteinL... StrikisD... LemmonV... BixbyJ. (2011)... Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.

No MeSH data available.


Related in: MedlinePlus