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Mullerian adenosarcoma of the uterus with sarcomatous overgrowth.

Singh R, Shameema S, Vijaya K, Kumar P - Clin Med Insights Case Rep (2010)

Bottom Line: On examination, a polypoid mass protruding through the cervix was seen which was biopsied.The surgical specimen was formalin fixed and paraffin embedded.In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

View Article: PubMed Central - PubMed

Affiliation: Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, (MGMCRI), Pillaiyarkuppam, Pondicherry, India.

ABSTRACT

Background and objectives: Mullerian adenosarcoma is an uncommon variant of mixed mesodermal tumour of the uterus. This is a case report of a 65 year old post-menopausal lady who presented with complaints of passing tissue fragments per vaginum for 2 days followed by spotting. On examination, a polypoid mass protruding through the cervix was seen which was biopsied. Following a preliminary histologic diagnosis of poorly differentiated sarcoma on the biopsy; the patient underwent total abdominal hysterectomy with bilateral salpingo-oopherectomy.

Method: The surgical specimen was formalin fixed and paraffin embedded. Haematoxylin and eosin stained sections were studied.

Result and conclusion: Histopathological examination of the polypoid mass revealed a tumour comprising of an admixture of benign endometrial glandular component with overgrowth of sarcomatous stromal component and heterologous elements. This may pose a problem in diagnosis due to its rarity, and hence its distinctive morphological features merit attention as described here. In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

No MeSH data available.


Related in: MedlinePlus

Haematoxylin and eosin staining (X 400) showing sarcomatous component.
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f2-ccrep-2010-027: Haematoxylin and eosin staining (X 400) showing sarcomatous component.

Mentions: Histopathological examination of the polypoid mass revealed a tumour with a predominantly stromal component (comprising more than 25% of the tumour) which was frankly sarcomatous composed of fascicles of poorly differentiated spindle shaped cells exhibiting mild to moderate nuclear atypia (Fig 2). Brisk mitosis, tumour giant cells and heterologous elements represented by rhabdomyosarcomatous differentiation were seen. (Fig 3) Extensive sampling revealed focal benign to atypical glands including occasional cystically dilated glands.


Mullerian adenosarcoma of the uterus with sarcomatous overgrowth.

Singh R, Shameema S, Vijaya K, Kumar P - Clin Med Insights Case Rep (2010)

Haematoxylin and eosin staining (X 400) showing sarcomatous component.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3046009&req=5

f2-ccrep-2010-027: Haematoxylin and eosin staining (X 400) showing sarcomatous component.
Mentions: Histopathological examination of the polypoid mass revealed a tumour with a predominantly stromal component (comprising more than 25% of the tumour) which was frankly sarcomatous composed of fascicles of poorly differentiated spindle shaped cells exhibiting mild to moderate nuclear atypia (Fig 2). Brisk mitosis, tumour giant cells and heterologous elements represented by rhabdomyosarcomatous differentiation were seen. (Fig 3) Extensive sampling revealed focal benign to atypical glands including occasional cystically dilated glands.

Bottom Line: On examination, a polypoid mass protruding through the cervix was seen which was biopsied.The surgical specimen was formalin fixed and paraffin embedded.In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

View Article: PubMed Central - PubMed

Affiliation: Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, (MGMCRI), Pillaiyarkuppam, Pondicherry, India.

ABSTRACT

Background and objectives: Mullerian adenosarcoma is an uncommon variant of mixed mesodermal tumour of the uterus. This is a case report of a 65 year old post-menopausal lady who presented with complaints of passing tissue fragments per vaginum for 2 days followed by spotting. On examination, a polypoid mass protruding through the cervix was seen which was biopsied. Following a preliminary histologic diagnosis of poorly differentiated sarcoma on the biopsy; the patient underwent total abdominal hysterectomy with bilateral salpingo-oopherectomy.

Method: The surgical specimen was formalin fixed and paraffin embedded. Haematoxylin and eosin stained sections were studied.

Result and conclusion: Histopathological examination of the polypoid mass revealed a tumour comprising of an admixture of benign endometrial glandular component with overgrowth of sarcomatous stromal component and heterologous elements. This may pose a problem in diagnosis due to its rarity, and hence its distinctive morphological features merit attention as described here. In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

No MeSH data available.


Related in: MedlinePlus