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Mullerian adenosarcoma of the uterus with sarcomatous overgrowth.

Singh R, Shameema S, Vijaya K, Kumar P - Clin Med Insights Case Rep (2010)

Bottom Line: On examination, a polypoid mass protruding through the cervix was seen which was biopsied.The surgical specimen was formalin fixed and paraffin embedded.In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

View Article: PubMed Central - PubMed

Affiliation: Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, (MGMCRI), Pillaiyarkuppam, Pondicherry, India.

ABSTRACT

Background and objectives: Mullerian adenosarcoma is an uncommon variant of mixed mesodermal tumour of the uterus. This is a case report of a 65 year old post-menopausal lady who presented with complaints of passing tissue fragments per vaginum for 2 days followed by spotting. On examination, a polypoid mass protruding through the cervix was seen which was biopsied. Following a preliminary histologic diagnosis of poorly differentiated sarcoma on the biopsy; the patient underwent total abdominal hysterectomy with bilateral salpingo-oopherectomy.

Method: The surgical specimen was formalin fixed and paraffin embedded. Haematoxylin and eosin stained sections were studied.

Result and conclusion: Histopathological examination of the polypoid mass revealed a tumour comprising of an admixture of benign endometrial glandular component with overgrowth of sarcomatous stromal component and heterologous elements. This may pose a problem in diagnosis due to its rarity, and hence its distinctive morphological features merit attention as described here. In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

No MeSH data available.


Related in: MedlinePlus

Gross photograph of the specimen showing a polypoid tumour arising from the uterine corpus and protruding through the os with glistening foci.
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Related In: Results  -  Collection


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f1-ccrep-2010-027: Gross photograph of the specimen showing a polypoid tumour arising from the uterine corpus and protruding through the os with glistening foci.

Mentions: The surgical specimen was formalin fixed and paraffin embedded. Gross examination of hysterectomy specimen with bilateral adnexa weighed 180 gm, sectioning revealed a polypoid mass measuring 7 × 6 × 4.5 cm arising from the posterior wall of uterine corpus distending the uterine cavity and protruding through the cervix (Fig 1). On sectioning the polypoid mass was firm grey-white, haemorrhagic with glistening/myxoid areas and foci of necrosis. The myometrium showed invasion upto 1 cm. The left uterine wall showed an intramural fibroid (<1 cm) with a firm whorled white cut surface. The cervix and bilateral adnexa appeared unremarkable. Haematoxylin and eosin stained sections were studied. For light microscopy, representative blocks embedded in paraffin were cut at 6 micron thickness.


Mullerian adenosarcoma of the uterus with sarcomatous overgrowth.

Singh R, Shameema S, Vijaya K, Kumar P - Clin Med Insights Case Rep (2010)

Gross photograph of the specimen showing a polypoid tumour arising from the uterine corpus and protruding through the os with glistening foci.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3046009&req=5

f1-ccrep-2010-027: Gross photograph of the specimen showing a polypoid tumour arising from the uterine corpus and protruding through the os with glistening foci.
Mentions: The surgical specimen was formalin fixed and paraffin embedded. Gross examination of hysterectomy specimen with bilateral adnexa weighed 180 gm, sectioning revealed a polypoid mass measuring 7 × 6 × 4.5 cm arising from the posterior wall of uterine corpus distending the uterine cavity and protruding through the cervix (Fig 1). On sectioning the polypoid mass was firm grey-white, haemorrhagic with glistening/myxoid areas and foci of necrosis. The myometrium showed invasion upto 1 cm. The left uterine wall showed an intramural fibroid (<1 cm) with a firm whorled white cut surface. The cervix and bilateral adnexa appeared unremarkable. Haematoxylin and eosin stained sections were studied. For light microscopy, representative blocks embedded in paraffin were cut at 6 micron thickness.

Bottom Line: On examination, a polypoid mass protruding through the cervix was seen which was biopsied.The surgical specimen was formalin fixed and paraffin embedded.In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

View Article: PubMed Central - PubMed

Affiliation: Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College and Research Institute, (MGMCRI), Pillaiyarkuppam, Pondicherry, India.

ABSTRACT

Background and objectives: Mullerian adenosarcoma is an uncommon variant of mixed mesodermal tumour of the uterus. This is a case report of a 65 year old post-menopausal lady who presented with complaints of passing tissue fragments per vaginum for 2 days followed by spotting. On examination, a polypoid mass protruding through the cervix was seen which was biopsied. Following a preliminary histologic diagnosis of poorly differentiated sarcoma on the biopsy; the patient underwent total abdominal hysterectomy with bilateral salpingo-oopherectomy.

Method: The surgical specimen was formalin fixed and paraffin embedded. Haematoxylin and eosin stained sections were studied.

Result and conclusion: Histopathological examination of the polypoid mass revealed a tumour comprising of an admixture of benign endometrial glandular component with overgrowth of sarcomatous stromal component and heterologous elements. This may pose a problem in diagnosis due to its rarity, and hence its distinctive morphological features merit attention as described here. In view of the rarity of this tumor, it is mandatory to do extensive histologic sampling to identify areas of sarcomatous overgrowth before arriving at a diagnosis of mullerian adenosarcoma as the clinical course and management vary.

No MeSH data available.


Related in: MedlinePlus