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Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients.

Ravishankaran P, Karunanithi R - World J Surg Oncol (2011)

Bottom Line: IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease.Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009).When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of General Surgery, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu, India. pravashu2624@gmail.com

ABSTRACT

Background: Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. The primary objective of this study was to determine the preoperative serum levels of IL-6 and CRP in breast carcinoma, and to correlate them with the staging of the disease and the prognosis.

Methods: 59 female patients admitted for breast cancer were identified for the study and were subjected to thorough evaluation. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumour size, lymph node (LN) metastasis, and tumour staging. Relevant investigations were made to find out the presence of distant metastasis. Statistical analysis of the data was then processed.

Results: Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels correlated with LN metastasis (P < 0.001, P < 0.001) and TNM stage (P < 0.001, P < 0.001). Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009). When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008). However, CRP evidenced no significance with regard to patient's OS levels. Serum IL-6 levels were correlated positively with CRP levels (r² = 0.579, P < 0.01)

Conclusion: Serum levels of IL-6 correlates well with the extent of tumor invasion, LN metastasis, distant metastasis and TNM staging thus enveloping all aspects of breast cancer.

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Related in: MedlinePlus

CRP and the characteristics of breast tumour. (A) CRP levels according to tumor depth. (B) CRP levels according to LN metastasis. (C) CRP levels according to distant metastasis. (D) CRP levels according to TNM staging.
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Figure 3: CRP and the characteristics of breast tumour. (A) CRP levels according to tumor depth. (B) CRP levels according to LN metastasis. (C) CRP levels according to distant metastasis. (D) CRP levels according to TNM staging.

Mentions: We noted that CRP levels did not differ significantly with tumour size (r = 0.374, P = 0.304). However we noted significant differences in serum CRP levels between patients with lymph node metastasis and those without lymph node metastasis (r = 0.690, P = 0.000). The median levels of CRP increased with increasing stage, and we also noted significant differences between the CRP level and cancer stage (the median level of CRP in stage 2a 10.1 ± 3.9 mg/dl, stage 2b 9.2 ± 4.6 mg/dl, stage 3a 13.8 ± 7.2 mg/dl, stage 3b 12.8 ± 9.2 mg/dl, stage 3c 21.5 ± 9.9 mg/dl and stage 4 37.5 ± 16.0; P < 0.001). The CRP levels did not differ significantly in patients with metastasis (37.4 ± 16.0 mg/dl) as compared to those without metastasis (13.9 ± 8.5 mg/dl, P = 0.061). Figure 3 shows (A) CRP levels according to tumor depth. (B) CRP levels according to LN metastasis. (C) CRP levels according to distant metastasis. (D) CRP levels according to TNM staging.


Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients.

Ravishankaran P, Karunanithi R - World J Surg Oncol (2011)

CRP and the characteristics of breast tumour. (A) CRP levels according to tumor depth. (B) CRP levels according to LN metastasis. (C) CRP levels according to distant metastasis. (D) CRP levels according to TNM staging.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3045973&req=5

Figure 3: CRP and the characteristics of breast tumour. (A) CRP levels according to tumor depth. (B) CRP levels according to LN metastasis. (C) CRP levels according to distant metastasis. (D) CRP levels according to TNM staging.
Mentions: We noted that CRP levels did not differ significantly with tumour size (r = 0.374, P = 0.304). However we noted significant differences in serum CRP levels between patients with lymph node metastasis and those without lymph node metastasis (r = 0.690, P = 0.000). The median levels of CRP increased with increasing stage, and we also noted significant differences between the CRP level and cancer stage (the median level of CRP in stage 2a 10.1 ± 3.9 mg/dl, stage 2b 9.2 ± 4.6 mg/dl, stage 3a 13.8 ± 7.2 mg/dl, stage 3b 12.8 ± 9.2 mg/dl, stage 3c 21.5 ± 9.9 mg/dl and stage 4 37.5 ± 16.0; P < 0.001). The CRP levels did not differ significantly in patients with metastasis (37.4 ± 16.0 mg/dl) as compared to those without metastasis (13.9 ± 8.5 mg/dl, P = 0.061). Figure 3 shows (A) CRP levels according to tumor depth. (B) CRP levels according to LN metastasis. (C) CRP levels according to distant metastasis. (D) CRP levels according to TNM staging.

Bottom Line: IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease.Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009).When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of General Surgery, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu, India. pravashu2624@gmail.com

ABSTRACT

Background: Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. The primary objective of this study was to determine the preoperative serum levels of IL-6 and CRP in breast carcinoma, and to correlate them with the staging of the disease and the prognosis.

Methods: 59 female patients admitted for breast cancer were identified for the study and were subjected to thorough evaluation. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumour size, lymph node (LN) metastasis, and tumour staging. Relevant investigations were made to find out the presence of distant metastasis. Statistical analysis of the data was then processed.

Results: Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels correlated with LN metastasis (P < 0.001, P < 0.001) and TNM stage (P < 0.001, P < 0.001). Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009). When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008). However, CRP evidenced no significance with regard to patient's OS levels. Serum IL-6 levels were correlated positively with CRP levels (r² = 0.579, P < 0.01)

Conclusion: Serum levels of IL-6 correlates well with the extent of tumor invasion, LN metastasis, distant metastasis and TNM staging thus enveloping all aspects of breast cancer.

Show MeSH
Related in: MedlinePlus