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Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients.

Ravishankaran P, Karunanithi R - World J Surg Oncol (2011)

Bottom Line: IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease.Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009).When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of General Surgery, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu, India. pravashu2624@gmail.com

ABSTRACT

Background: Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. The primary objective of this study was to determine the preoperative serum levels of IL-6 and CRP in breast carcinoma, and to correlate them with the staging of the disease and the prognosis.

Methods: 59 female patients admitted for breast cancer were identified for the study and were subjected to thorough evaluation. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumour size, lymph node (LN) metastasis, and tumour staging. Relevant investigations were made to find out the presence of distant metastasis. Statistical analysis of the data was then processed.

Results: Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels correlated with LN metastasis (P < 0.001, P < 0.001) and TNM stage (P < 0.001, P < 0.001). Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009). When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008). However, CRP evidenced no significance with regard to patient's OS levels. Serum IL-6 levels were correlated positively with CRP levels (r² = 0.579, P < 0.01)

Conclusion: Serum levels of IL-6 correlates well with the extent of tumor invasion, LN metastasis, distant metastasis and TNM staging thus enveloping all aspects of breast cancer.

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Related in: MedlinePlus

Overall survival curve according to IL-6 (Interleukin-6) levels.
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Figure 2: Overall survival curve according to IL-6 (Interleukin-6) levels.

Mentions: We noted significant differences in the Overall Survival between the two groups (82.7% versus 97.2%; P = 0.008) See Figure 2 for Overall survival curve according to IL-6 (Interleukin-6) levels.


Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients.

Ravishankaran P, Karunanithi R - World J Surg Oncol (2011)

Overall survival curve according to IL-6 (Interleukin-6) levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3045973&req=5

Figure 2: Overall survival curve according to IL-6 (Interleukin-6) levels.
Mentions: We noted significant differences in the Overall Survival between the two groups (82.7% versus 97.2%; P = 0.008) See Figure 2 for Overall survival curve according to IL-6 (Interleukin-6) levels.

Bottom Line: IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease.Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009).When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of General Surgery, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu, India. pravashu2624@gmail.com

ABSTRACT

Background: Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. The primary objective of this study was to determine the preoperative serum levels of IL-6 and CRP in breast carcinoma, and to correlate them with the staging of the disease and the prognosis.

Methods: 59 female patients admitted for breast cancer were identified for the study and were subjected to thorough evaluation. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumour size, lymph node (LN) metastasis, and tumour staging. Relevant investigations were made to find out the presence of distant metastasis. Statistical analysis of the data was then processed.

Results: Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels correlated with LN metastasis (P < 0.001, P < 0.001) and TNM stage (P < 0.001, P < 0.001). Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009). When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008). However, CRP evidenced no significance with regard to patient's OS levels. Serum IL-6 levels were correlated positively with CRP levels (r² = 0.579, P < 0.01)

Conclusion: Serum levels of IL-6 correlates well with the extent of tumor invasion, LN metastasis, distant metastasis and TNM staging thus enveloping all aspects of breast cancer.

Show MeSH
Related in: MedlinePlus