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Solitary splenic metastasis from ovarian carcinosarcoma: a case report.

Olsen AB, Pargman S, Gillespie T - J Med Case Rep (2011)

Bottom Line: The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma.They can arise anywhere in the female genital tract, most commonly from the endometrium.Even though it is rare, carcinosarcomas can metastasize to the spleen.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of General Surgery, St, Joseph's Hospital and Medical Center, 350 W, Thomas Road, Phoenix, AZ 85013, USA. alex.olsen@chw.edu.

ABSTRACT

Introduction: Metastatic tumors to the spleen are rare but are usually found in conjunction with metastasis to other organs. The most common sources of splenic metastasis are breast, lung and colorectal cancers as well as melanoma and ovarian carcinoma. A solitary carcinosarcoma metastasis to the spleen of any origin is very rare. To the best of our knowledge, there are fewer than 30 reported cases of ovarian primary tumors with solitary metastasis to the spleen, and only three solitary primary carcinosarcomas to the spleen have been reported, of which one is female. We present what is, to the best of our knowledge, the first case of a solitary metastatic carcinosarcoma to the spleen arising from a primary ovarian carcinsarcoma.

Case presentation: A 72-year-old Hispanic woman status post-total abdominal hysterectomy for ovarian carcinosarcoma presented with complaints of early satiety and abdominal pain for the past two months with a 30-lb unintentional weight loss. An initial computed tomographic scan of her abdomen and pelvis revealed a 30 cm × 27 cm splenic mass with displacement of the left kidney, stomach and liver. The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma.

Conclusion: Carcinosarcoma of the spleen is a rare tumor. Carcinosarcomas are a biphasic neoplasm comprising malignant epithelial and mesenchymal components arising from a stem cell capable of differentiation. They can arise anywhere in the female genital tract, most commonly from the endometrium. Even though it is rare, carcinosarcomas can metastasize to the spleen. This unique case of a solitary splenic metastasis from ovarian carcinosarcoma has particular interest in medicine, especially for the specialties of surgical oncology, pathology and hematology/oncology.

No MeSH data available.


Related in: MedlinePlus

A computed tomographic scan of a large splenic mass (coronal view). See attached arrow.
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Figure 1: A computed tomographic scan of a large splenic mass (coronal view). See attached arrow.

Mentions: A 72-year-old Hispanic woman presented with complaints of early satiety and abdominal pain for the past two months with a 30-lb unintentional weight loss. Her medical history included a total abdominal hysterectomy with bilateral salpingo-oophorectomy performed in Mexico for ovarian cancer seven years previously. The pathology report described an ovarian carcinosarcoma. Her physical examination revealed a large left upper quadrant mass which was tender to palpation. An initial computed tomographic scan of her abdomen and pelvis revealed a 30 cm × 27 cm splenic mass in coronal view with displacement of the left kidney, stomach and liver (see attached arrow in Figure 1). No other masses concerning metastasis were noted.


Solitary splenic metastasis from ovarian carcinosarcoma: a case report.

Olsen AB, Pargman S, Gillespie T - J Med Case Rep (2011)

A computed tomographic scan of a large splenic mass (coronal view). See attached arrow.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3045934&req=5

Figure 1: A computed tomographic scan of a large splenic mass (coronal view). See attached arrow.
Mentions: A 72-year-old Hispanic woman presented with complaints of early satiety and abdominal pain for the past two months with a 30-lb unintentional weight loss. Her medical history included a total abdominal hysterectomy with bilateral salpingo-oophorectomy performed in Mexico for ovarian cancer seven years previously. The pathology report described an ovarian carcinosarcoma. Her physical examination revealed a large left upper quadrant mass which was tender to palpation. An initial computed tomographic scan of her abdomen and pelvis revealed a 30 cm × 27 cm splenic mass in coronal view with displacement of the left kidney, stomach and liver (see attached arrow in Figure 1). No other masses concerning metastasis were noted.

Bottom Line: The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma.They can arise anywhere in the female genital tract, most commonly from the endometrium.Even though it is rare, carcinosarcomas can metastasize to the spleen.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of General Surgery, St, Joseph's Hospital and Medical Center, 350 W, Thomas Road, Phoenix, AZ 85013, USA. alex.olsen@chw.edu.

ABSTRACT

Introduction: Metastatic tumors to the spleen are rare but are usually found in conjunction with metastasis to other organs. The most common sources of splenic metastasis are breast, lung and colorectal cancers as well as melanoma and ovarian carcinoma. A solitary carcinosarcoma metastasis to the spleen of any origin is very rare. To the best of our knowledge, there are fewer than 30 reported cases of ovarian primary tumors with solitary metastasis to the spleen, and only three solitary primary carcinosarcomas to the spleen have been reported, of which one is female. We present what is, to the best of our knowledge, the first case of a solitary metastatic carcinosarcoma to the spleen arising from a primary ovarian carcinsarcoma.

Case presentation: A 72-year-old Hispanic woman status post-total abdominal hysterectomy for ovarian carcinosarcoma presented with complaints of early satiety and abdominal pain for the past two months with a 30-lb unintentional weight loss. An initial computed tomographic scan of her abdomen and pelvis revealed a 30 cm × 27 cm splenic mass with displacement of the left kidney, stomach and liver. The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma.

Conclusion: Carcinosarcoma of the spleen is a rare tumor. Carcinosarcomas are a biphasic neoplasm comprising malignant epithelial and mesenchymal components arising from a stem cell capable of differentiation. They can arise anywhere in the female genital tract, most commonly from the endometrium. Even though it is rare, carcinosarcomas can metastasize to the spleen. This unique case of a solitary splenic metastasis from ovarian carcinosarcoma has particular interest in medicine, especially for the specialties of surgical oncology, pathology and hematology/oncology.

No MeSH data available.


Related in: MedlinePlus